首页AutophagyFatty Acid Synthase
Fatty Acid Synthase
T0686 Orlistat Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.
T0846 L(-)-Carnitine L(-)-Carnitine is an amino acid derivative. L(-)-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy pr
T0988 Trimetazidine dihydrochloride Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also us
T1426 Pyrazinamide Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
T2468 A 769662 A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T4380 Ac-CoA Synthase Inhibitor1 ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
TJS0387 Deoxyrhapontin 1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explai
TQ0260 Cerulenin Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
T7947 FT113 FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
TN1365 Albaspidin AP Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inh
TN1751 Hydroxycitric acid (-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive
TN1803 Isoscoparin Isoscoparin has antioxidant, and anti-adipogenic effects, it may be a potential therapeutic agent for the prevention and treatment of obesity. Isoscoparin can significantly inhibit
TN2083 Pinostrobin chalcone Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through the inhibition of adi
TN1440 Beta-Hydroxyisovalerylshikonin Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor
T10656 trans-C75 trans-C75 is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
T14298 Rimiducid Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is
T14570 BI99179 BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral admi
T11266L FAS-IN-1 Tosylate FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
TN2535 1-Hydroxy-2-oxopomolic acid 1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN4094 Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κ
T11557 FASN-IN-3 FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
T15271 FASN-IN-2 FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
T15271 FASN-IN-2 FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
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