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FXR
T1789 Obeticholic Acid Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T2015 Fexaramine Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T2202 Lithocholic acid Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorpt
T2233 GW 4064 GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T2968 Hyodeoxycholic acid Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T6053 Turofexorate Isopropyl Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T6690 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T4379 Tropifexor Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T5264 Androsterone Androsterone is a metabolic product of testosterone and can activate Farnesoid X Receptor (FXR).
T7436 Cilofexor Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T7886 Nidufexor Nidufexor is an agonist for the farnesoid X receptor (FXR).
TQ0252 BAR502 BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T8471 Vonafexor Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T13093 Tauro-β-muricholic acid sodium Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T11426 Gly-β-MCA Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
T15818 LY367385 LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM for mGlu5a, LY3673
T12583L (-)-PX20606 trans isomer (-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
TN4628 Nelumol A Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists.
T13092 Tauro-Obeticholic acid Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T11428 Glyco-Obeticholic acid Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T8895 Altenusin Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T6344 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
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