||Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and u
||Quinestrol is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
||Toremifene is a selective estrogen-receptor modulator (SERM).
||Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
||Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and end
||Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.
||Ethisterone is a progestogen hormone.
||Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
||Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
||Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN
||XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
||Natamycin is a Polyene Antimicrobial.
||Tamoxifen Z-isomer citrate
||Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
||Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
||Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
||Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ES
||Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
||Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
||Clomifene Citrate is a selective estrogen receptor modulator.
||Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
||Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscula
||Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
||Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mout
||Methyldienedione is an anabolic steroid and a precursor to dienolone.
||Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the est
||Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydr
||Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthes
||Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and ut
||Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropi
||Gestodene is a progestogen hormonal contraceptive.
||Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic an
||Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
||Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
||Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects o
||Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY,
||Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
||Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during e
||5Beta-Pregnane-3Alpha, 20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alph
||Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
||Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
||Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
||Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
||DY131 is a novel selective agonist of ERRβ and ERRγ.
||Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
||Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the proge
||Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
||Allylestrenol is a synthetic steroid with progestational activity.
||Etonogestrel is a steroidal progestin used as hormonal contraceptives.
||Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly est
||Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities
||Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimul
||Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is an immunomodulator
||Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9
||Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
||Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
||Endoxifen E-isomer hydrochloride
||Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
||β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein
||Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding depend
||Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
||WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
||AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
||Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activit
||LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
||Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
||S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprot
||Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
||Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atro
||STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.
||Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
||Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
||Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
||Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
||(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has
||PHTPP is a selective ERβ antagonist.
||4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
||Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteop
||GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
||Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
||GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
||H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
||PROTAC ERRα ligand 2
||PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
||Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM.
||DPN is an selective agonist of estrogen receptor β (ERβ) .
||Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
||Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
||Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
||27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
||Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
||Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
||Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
||Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
||Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
||Segetalin A has estrogen-like activity.
||Allura Red AC
||Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
||Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contribu
||Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrog
||Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate(IC50 =49
||GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
||NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
||OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
||Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
||CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and 2200 nM for MGERα,
||PROTAC ERRα ligand 1
||PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
||Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .
||Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
||Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
||ERRγ Inverse Agonist 1
||ERRγ Inverse Agonist 1 is a potent, selective and orally bioavailable Estrogen-related Receptor grammar inverse agonist, with an IC50 of 40 nM.
||Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestr
||(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
||NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
||(+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogen
||SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation)
||Ferrous Bisglycinate is used in the fortification of infant formulations and foods.
||(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
||SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
||(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ) inverse agonist(IC5
||4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of br
||Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.