T1655 |
Ambrisentan |
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme eleva |
T2561 |
Macitentan |
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
T3194 |
Ro 46-2005 |
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM). |
T3474 |
RO 46-8443 |
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibit |
T6258 |
Zibotentan |
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. |
T6264 |
Bosentan |
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. |
T6265 |
Bosentan Hydrate |
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. |
T6672 |
Sitaxentan sodium |
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors. |
T6792 |
BQ123 |
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
T5458 |
Darusentan |
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries |
T7817 |
Aprocitentan |
Aprocitentan is ETA and ETB antagonist . |
TQ0259 |
Atrasentan |
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA). |
TQ0270 |
Atrasentan hydrochloride |
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA). |
TQ0282 |
Avosentan |
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor). |
TN4606 |
Myriceric acid C |
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma. |
T5355 |
Sparsentan |
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively) |