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Dynamin

Dynamin is a GTPase responsible for exocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus. Dynamin family members also play a role in many processes including division of organelles, cytokinesis and microbial pathogen resistance.

产品编号 产品名称
T6822 Hydroxy-Dynasore Hydroxy-Dynasore 是 Dynasore 结构模拟类似物,是一种改进的,低细胞毒性的dynamin通用抑制剂,抑制 dynamin 依赖性转铁蛋白的内吞作用的IC50为 5.7 μM,对大脑重组 dynamin I 和重组鼠 dynamin II 的IC50值分别为 0.38 μM 和 2.3μM。
TP1907L1 Dynamin inhibitory peptide, myristoylated acetate Dynamin inhibitory peptide, myristoylated acetate is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis.
T22445 Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide 是 Dynamin I 的抑制剂 (IC50 : 1.9 μM),也抑制 Dynamin Ⅱ。
T1907 Mdivi-1 Mdivi-1 是选择性的发动蛋白相关蛋白 1 (Drp1) 抑制剂。Mdivi-1 是一种有效的线粒体分裂/线粒体自噬抑制剂。
T1848 Dynasore Dynasore 是一种可渗透细胞的化学物质,可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。 它还抑制线粒体动力蛋白 Drp1,对其他小 GTPase 没有影响。
T22981 Tetradecyltrimethylammonium bromide MitMAB 是一种具有不对称结构的阳离子表面活性剂,是一种有机结构单元。
T3898 Schaftoside Schaftoside 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达,还降低 Drp1 表达和磷酸化,并减少线粒体分裂,具有抗氧化和抗癌活性。
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