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DNA Alkylation
T0377 Clofazimine Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against va
T0707 Cyclophosphamide monohydrate Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T0923 Busulfan Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears t
T0942 Quinacrine dihydrochloride Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appear
T0975 Chloroambucil Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption o
T11056 DLK-IN-1 DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS
T11440 GNE-8505 GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T1241 Altretamine Altretamine is an alkylating agent with antineoplastic activity.
T1250 Triethylenethiophosphoramide Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T12813L Seco-Duocarmycin SA Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T1343L Crystal Violet Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
T1507 Streptozocin Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
T1548 8-Methoxypsoralen Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of
T1601 Lomustine Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
T17159 Treosulfan Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T17212 VAL-083 VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T19300 Duocarmycin Analog Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T2495 Lomeguatrib Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T3091 Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T3707 GNE3511 GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T4024 Norharmane Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most
T4368 Miriplatin Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T5846 Methylnitronitrosoguanidine Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
T6057 URMC099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T6798 Tretazicar CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0
T7221 Satraplatin Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malig
T7539 O6-Benzylguanine O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
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