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Cysteine Protease
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0789 PMSF Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
T1080 2-Aminoethanethiol Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
T1850 Balicatib Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
T2470 Calpain Inhibitor III Calpain Inhibitor III is a Cysteine protease.
T2493 PD 151746 PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
T3088 N-Ethylmaleimide N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T3420 CA-074 methyl ester CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
T6035 Odanacatib Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
T6037 E64 E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T6040 Aloxistatin Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and
T6432 Calpeptin Calpeptin is a potent, cell-permeable calpain inhibitor.
T6564 Leupeptin Hemisulfate Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
T6573 Loxistatin Acid Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
T6738 Z-FA-FMK Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T6925 P005091 P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
T4403 AX-024 HCl AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), I
T5211 NSC185058 NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T7451 2-cyano-Pyrimidine 2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
TQ0116 LY 3000328 LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
T12051 MIV-247 MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
T10924 Cysteine protease inhibitor-2 Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with
T12819 S130 S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
T12909 SID 26681509 SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
T13705 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T11554 Cathepsin Inhibitor 2 Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T15641 K777 K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is also a CYP3A4 inhibit
T13439 (RS)-Butyryltimolol (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is a β-adrenergic blocker.
T16104 ML-9 ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chai
T16106 ML224 ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
T16394 ONO-5334 ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential f
T16474 Petesicatib Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T11846 LHVS LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.
T11896 LV-320 LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 is a potent and uncompetitive ATG4B inhibitor with a
T21616 L 006235 L 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
T2154 MG132 MG-132 is a potent cell-permeable 20S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain (IC50: 1.2 μM).
T6583 MG101 MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T17026 Tecovirimat Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection.Tecovirimat is a novel antiviral potent and selective activity against mul
T17026 Tecovirimat Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection.Tecovirimat is a novel antiviral potent and selective activity against mul
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