T1830 |
BX795 |
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, t |
T1837 |
BX912 |
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC etc. |
T2033 |
BML277 |
BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor. |
T2485 |
Baricitinib |
Baricitinib is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activities. |
T2517 |
SCH900776 |
CHK1 Inhibitor MK-8776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. |
T3700 |
SCH900776 S-isomer |
SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependen |
T6028 |
PF477736 |
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. |
T6084 |
Rabusertib |
Rabusertib is an inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Canc |
T6093 |
AZD7762 |
AZD7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. |
T6156 |
S-Ruxolitinib |
Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor. |
T6350 |
CHIR124 |
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. |
T6931 |
PD0166285 |
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. |
T4310 |
Prexasertib |
Prexasertib is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. |
T4327 |
Prexasertib dihydrochloride |
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. |
T7080 |
CCT245737 |
CCT245737 is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). |
T7300 |
GDC-0575 |
GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM). |
TN1458 |
Buddlejasaponin IV |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation. |
T10325 |
ANI-7 |
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breas |
T14904 |
CCT244747 |
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). |
T13148 |
CHK-IN-1 |
CHK-IN-1 is a CHK1 and CHK2 inhibitor, has anti-proliferative activities. |
T10718 |
CCT241533 |
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM). |
T10718L |
CCT241533 hydrochloride |
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM). |
T10793 |
CHK1 inhibitor |
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor. |
T10790 |
CHK1-IN-2 |
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM). |
T10791 |
CHK1-IN-3 |
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM). |
T10792 |
CHK1-IN-4 |
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity. |
T16165 |
Myriocin |
Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-palmitoyl-transferase |
T16848 |
SB-218078 |
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhib |
T17223 |
VER-00158411 |
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively). |