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Calcium Channel
T0077 Dantrolene sodium salt Dantrolene is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neuromuscu
T0112 Diltiazem hydrochloride Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
T0119 Nitrendipine Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does
T0121 Azelnidipine Azelnidipine is a dihydropyridine used as calcium channel blocker.
T0145 Felodipine Felodipine is a longlasting 1, 4-dihydropyridine calcium channel repressor.
T0163 Nisoldipine Nisoldipine is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
T0192 Levetiracetam Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been li
T0193 Manidipine dihydrochloride Manidipine dihydrochloride is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).
T0207 Ranolazine dihydrochloride Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect bloo
T0231 Amlodipine Besylate Amlodipine Besylate is a long-lasting calcium channel blocker.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is
T0283 Trimethadione Trimethadione is a dione-type anticonvulsant with antiepileptic activity.
T0327 Fendiline hydrochloride Fendiline is a non-selective blocker of calcium channel.
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0388 Cilnidipine Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
T0728 Ethosuximide Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
T0806 Flunarizine dihydrochloride Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine hydrochloride is effective in the prophylaxis of
T0903 Stugeron Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DI
T0957 Isradipine Isradipine is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calcium ion channels of c
T0999 Clevidipine butyrate Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not
T1010 Verapamil hydrochloride Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T1146 Nifedipine Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscl
T1197 Trimebutine maleate Trimebutine maleate is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors served as a spasmolyti
T1215 Nicardipine hydrochloride Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine
T1234 5,5-Dimethyloxazolidine-2,4-dione An anticonvulsant that is the active metabolite of TRIMETHADIONE.
T1385 Amlodipine Amlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
T1422 Nilvadipine Nilvadipine, a calcium channel blocker (CCB), is utilized for treatment of hypertension.
T1435 Praziquantel Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and para
T1439 Lacidipine Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex t
T1474 Otilonium bromide Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
T1545 (S)-Amlodipine Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, a
T1641 Strontium ranelate Strontium ranelate, a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The dru
T1730 NPS 2143 NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor.
T2323 Efonidipine Efonidipine(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.
T2519 Lercanidipine Lercanidipine is a calcium channel blocker of the dihydropyridine class.
T2604 1-Ethyl-2-benzimidazolinone 1-Ethyl-2-benzimidazolinone is a calium channel agonist.
T2996 Tetrandrine Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade
T3377 phenylalanine Phenylalanine is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
T3484 (±)-trans-ACPD (±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the gro
T3508 SEA0400 SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
T3543 NS 638 NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
T3703 ABT639 ABT-639 is a potent and selective T-type calcium channel blocker.
T6571 Lomerizine hydrochloride Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
T6577 Manidipine Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized
T6633 Ranolazine Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia i
T6777 Bay K 8644 Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
T6874 Lercanidipine hydrochloride Lercanidipine is a calcium channel blocker of the dihydropyridine class.
T4284 (S)-Amlodipine Besylate (103129-82-4(free base)) Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipine belongs to the dih
T3S1916 Heteroclitin D 1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor.
TCS0102 Pulegone 1. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T4669 Fantofarone Fantofarone is a highly potent Calcium Channel antagonist.
T5120 alpha-L-Rhamnose Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-si
T5376 Aranidipine Aranidipine (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
T5391 Bepridil hydrochloride Bepridil is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
T5632 MK-8998 MK-8998 as potent inhibitors of T-type calcium channels.
T5856 Barnidipine Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery
T7216 Mirogabalin Mirogabalin is a calcium channel blocker with analgesic effects.
T7334 NP118809 NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
T7338 DHBP dibromide DHBP dibromide is calcium release and a muscle relaxant inhibitor.
T7550 Barnidipine Barnidipine is a calcium channel blocker.
T7603 Pinaverium bromide Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
T7373 CDN1163 CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).
TQ0144 (S)-(-)-Bay K 8644 (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. It activates Ba2+ currents (IBa) (EC50: 32 nM).
TQ0145 (R)-(+)-Bay K 8644 (R)-(+)-Bay K 8644 is a calcium channel inhibitor. It inhibits Ba2+ currents (IBa) (IC50: 975 nM).
TQ0153 Mibefradil Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).
TQ0302 Thapsigargin Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
T6507 Gabapentin HCl Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
T0702 Gabapentin Gabapentin is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T6S1500 Ginsenoside-Rf Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
T8401 Efonidipine hydrochloride monoethanolate Efonidipine hydrochloride monoethanolate is a Ca(2+)-channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortical Carcinoma Cells
TN1154 6-Methoxyluteolin 6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
TN1367 Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of a
TN1519 Coclaurine (+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking actions.
TN1544 D-Menthol Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur
TN1588 Dihydroisotanshinone I Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and i
TN1913 Marmin Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the
TN2054 Periplocymarin Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
TN2116 Pteropodine Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows stro
TN2211 Silybin B Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibition and apoptosis i
TN1032 Geissoschizine methyl ether Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a po
TN1121 Evocarpine Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
TN1136 Procyanidin A1 Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.
TN1338 7Beta-Hydroxycholesterol 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.
TN1721 Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small ce
TN1757 Hypophyllanthin Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
TN2078 Pinocembrin chalcone Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic activation of heter
TN2169 Saikogenin D Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is at
TN2287 Turkesterone Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistres
TN2322 Yangambin Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatati
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with
TN2215 Sodium taurochenodeoxycholate Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious anti-inflammatory an
T12032 Mibefradil dihydrochloride Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM and 18.6 μM, respe
T12108 MRS1845 MRS1845 is a selective inhibitor of store-operated calcium (SOC) channel (IC50 of 1.7 μM).
T12153 N-type calcium channel blocker-1 N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
T12204 NecroX-5 NecroX-5 is a derivative of the NecroX and with anti-inflammatory and anti-cancer activity.
T12205 Ned 19 Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
T12244 Norverapamil Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
T12322 ORM-10962 ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55 nM , respectively).
T12358 Palonidipine Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.
T12385 PD0176078 PD0176078 is a newly blocker of N-type Calcium channel.
T19253 Cyclic ADP-​ribose Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosoli
T10991 Dehydronitrosonisoldipine Dehydronitrosonisoldipine is a calcium channel antagonist.
T11080 Dopropidil Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.
T11102 DS16570511 DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.
T12625 (R)-Lercanidipine D3 hydrochloride (R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride) is a calcium channel blocker.
T12626 (R)-Lercanidipine hydrochloride (R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a blocker of calcium channel.
T14872 Carboxyamidotriazole Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammatory, anti-tumor, and
T15257 Etripamil Etripamil is an antagonist of short-acting L-type calcium-channel for the treatment of Paroxysmal Supraventricular Tachycardia.
T15301 Fluspirilene Fluspirilene is a non-competitive L-type calcium channel antagonist (IC50: 0.03 μM). It is a long-acting injectable depot antipsychotic drug used for schizophrenia.
T11353L Gallopamil hydrochloride Gallopamil hydrochloride is a methoxy derivative of Verapamil and is a phenylalkylamine calcium antagonist. It is a potent antiarrhythmic and vasodilator agent. Gallopamil hydrochl
T13879 (S)-Verapamil hydrochloride (S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.
T12845 SB-423557 SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM
T12880 Semotiadil recemate fumarate Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel antagonist of vasoselective Ca2+ channel.
T12993 SQ-31765 SQ-31765 is a blocker of benzazepine calcium channel.
T13117 Teludipine hydrochloride Teludipine hydrochloride is a blocker of lipophilic calcium channel.
T13154 Tiapamil hydrochloride Tiapamil hydrochloride is a blocker of calcium channel.
T11353 Gallopamil Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyv
TP2170 CALP3 TFA(261969-05-5 free base) CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodu
T10713 CCR4 antagonist 2 CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Mi
T11553 Heptamidine dimethanesulfonate Heptamidine dimethanesulfonate is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM), selectively kills melanoma cells with S100B over those
T13219 TTA-Q6 TTA-Q6 is a selective antagonist of T-type Ca2+ channel, used in the neurological disease.
T13250 UK51656 UK51656 is an antagonist of calcium (IC50: 4 nM).
T13328 AE0047 Hydrochloride AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
T15553 Iganidipine Iganidipine is an antagonist of Ca2+ .
T15740 Levamlodipine besylate Levamlodipine besylate is a powerful dihydropyridine calcium channel blocker. It has possessing vasodilation properties and used in the treatment of hypertension and angina.
T15755 Lidoflazine Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular
T11666 IPR-803 IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity.IPR-803 is a potent inhibitor of the uPAR•uPA protein-protein interaction (PPI).
T16357 NSC 663284 NSC 663284 is a cell-permeable and irreversible Cdc25 dual specificity phosphatase inhibitor (IC50 for Cdc25B2: 0.21 μM). NSC 663284 inhibits NSD2 (IC50 of 170 nM) through direct
T3904 Gomisin J Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflamma
T16447 β-Amino Acid Imagabalin Hydrochloride β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.
T16571 Pranidipine Pranidipine is an effective, long-acting 1,4-dihydropyridine calcium channel blocker. It also has antihypertensive activity.
T15423 GSK-7975A GSK-7975A is a potent and orally available inhibitor of CRAC channel.
T11979 McN5691 McN5691 is a voltage sensitive calcium channel blocker.
T16887 Sipatrigine Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
T12205L trans-Ned 19 trans-Ned 19 is a NAADP antagonist and TPC blocker and inhibits the calcium signal in human umbilical vein endothelial cells and the rat aorta relaxation in response to low histami
T2S0118 Daurinoline Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function
T3229 Cytochalasin D Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes suc
T3S0289 Araloside X Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA me
T4001 Euxanthone Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasodilator effect throu
T4243 Reticuline Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine. Reticuline possesses potent central ne
T7009 Soyacerebroside II Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious inhibitory activit
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid s
TN2703 2',3'-Dihydroxy-4'-methoxyacetophenone 2,3-Dihydroxy-4-methoxyacetophenone is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
TN2918 3-Acetoxy-8(17),13E-labdadien-15-oic acid ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN3260 8(14),15-Isopimaradien-3-ol ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for mo
TN3319 9-Hydroxycanthin-6-one 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably
TN3466 Atherosperminine Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activi
TN3568 Calceolarioside A Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-
TN3660 Cinnamyl caffeate Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell a
TN3831 Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the aggregation and AT
TN3844 Didrovaltrate Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state,
TN4051 Fargesone B Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
TN4303 Isokaempferide Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil de
TMA0805 Lupanine Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves gluco
TMA0763 Methyl 3,4,5-trimethoxycinnamate Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
TN4819 (-)-Praeruptorin A (-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium
TN5073 Strophanthidine Strophanthidin can induce calcium overload in vivo.
TN5109 Taxezopidine L Taxezopidines K and taxezopidine L can markedly inhibit Ca2+-induced depolymerization of microtubules.
TN5234 Vindorosine Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
TN5279 Zeorin Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows pote
T8674 SR33805 SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
T16339 Norverapamil hydrochloride Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) fu
T0368 Cinepazide maleate Cinepazide maleate, a maleate salt form of cinepazide, is a vasodilator.
T4054 Dantrolene sodium hemiheptahydrate Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine recepto
T2878 Ginsenoside Rd Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
T2782L Catharanthine Tartrate(2468-21-5(free base)) Catharanthine Tartrate is a natural product isolated from Madagascar periwinkle, Catharanthine Tartrate inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pr
T21454 Nicardipine Nicardipine hydrochloride, a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure.
T19765 MDK-4025 MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.
T8867 RO2959 Hydrochloride RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
T8815 Azumolene Azumolene
T8448 ZSET-1446 ZSET-1446 is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
T6S0659 Rhynchophylline 1. Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can i
T6395 Astragaloside A Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases.
T4693 2-APB 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).
T8681 HA-1004 dihydrochloride HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T8681 HA-1004 dihydrochloride HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T15027 Cyclopiazonic acid Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomol
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