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T10156 CCR3 antagonist 1 CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T10425 AZ084 AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T10708 CCR1 antagonist 6 CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
T10709 CCR1 antagonist 7 CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
T10710 CCR1 antagonist 9 CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10711 CCR2 antagonist 1 CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10712 CCR2 antagonist 3 CCR2 antagonist 3 is a CCR2 antagonist.
T10714 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10756 Cenicriviroc Mesylate Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T11472L Molibresib besylate Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T11521 GW 766994 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11699 J-113863 J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR
T11704 JAK-IN-3 JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T12076L ML218 ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel (Cav3.1, Cav3.2, Ca
T12419L PF-04634817 PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also h
T12773 RS102895 hydrochloride RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T14307 Aplaviroc Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T14373 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2
T14688 BMS CCR2 22 BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) and potent functional
T14899 CCR1 antagonist 8 CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T14900 CCR2-RA-[R] CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T14909 CCX140 CCX140 (CCX140-B) is an antagonist of CCR2.
T15253 CCX354 CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T17274 YM022 YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase
T2375 BX471 BX471 is a potent, selective non-peptide CCR1 antagonist.
T3188 NSC5844 NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T3327 Arteether Arteether is a new, fast-acting antimalarial drug.
T3360 ZK 756326 ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-
T3430 PF4136309 INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T3435 Vicriviroc maleate Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development
T4300 AZD2098 AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T4584 BMS813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T4674 SB 297006 SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 25
T5384 RS 504393 RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T6016 Maraviroc Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5
T6413 Bindarit Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T7499 TAK-779 TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T7624 DAPTA(TFA) DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
TN2951 3-(hydroxymethyl)cyclopentanone 3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV
TQ0103 INCB3344 INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM (mCCR2) and in 3.8
TQ0182 MK-0812 MK-0812 is an effective and specific CCR2 antagonist.
TQ0283 RS102895 RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.
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