首页AutophagyBeta Amyloid
Beta Amyloid
T0883 Homotaurine Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also
T2262 CHF5074 CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T2625 MK0752 MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T2639 LY2811376 LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 ov
T3394 Timosaponin BII Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1
T6274 RO4929097 RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T6495 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
T4422 Edonerpic maleate Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
T5810 TABERSONINE HYDROCHLORIDE TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
T7490 ARN2966 ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
T7527 Frentizole Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
TQ0026 MDR-1339 MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T7562 β-Amyloid 31-35(TFA) β-Amyloid 31-35(TFA) is the shortest sequence of native Amyloid-β peptide.
T6202 DAPT DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T8012 Scyllo-Inositol Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease.
T7905 PBD-150 PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T7680 GSNKGAIIGLM(131602-53-4(free base)) GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
TN1091 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1712 Gossypin Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activati
TN1341 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it has multifunctional a
TN1725 Hederacolchiside E Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by blocking bradykinin
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentati
TN1919 Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-se
TN1038 Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abet
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under active oxygen stress st
TN2082 Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage
TN2100 Pratensein Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T14525 Begacestat Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
T14673 BMS 299897 BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
T10453 BACE1-IN-5 BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG inhibition and P-gp
T19011 Hoechst 34580 Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T19013 Hoechst 34580 tetrahydrochloride Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TP1856 Colivelin Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
TMS1461 Otophylloside B Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the e
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insig
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects
TN3618 Cedrin Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement
TN4571 Mirabijalone D Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation o
TN4865 Putraflavone Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
T19892 BSBM7 BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
T14284 Amyloid beta-peptide(25-35) Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
T2872 Ginsenoside Re Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T2777 Ginsenoside Rg1 Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal
T19011L Hoechst 34580 xHCl(23555-00-2(free base) Hoechst 34580 xHCl is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T2212 Geniposide Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has b
TP1786L Amyloid β-Protein 10-20 acetate(152286-31-2 free base) Amyloid β-Protein (10-20) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase p
TP1214L β-Amyloid 15-21 acetate β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation.
TP1007 Amyloid β-Peptide (1-42) human Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
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