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Androgen Receptor
T0135 Estradiol valerate β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
T0272 Nilutamide Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors,
T0380 Bicalutamide Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
T0476 Abbolactone Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T0489 Flutamide Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
T0856 Dehydroepiandrosterone acetate Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
T0856L Dehydroepiandrosterone Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although the mechanisms of act
T10946 D4-abiraterone D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an
T1167 Cyproterone acetate Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor ce
T13273 UT-34 UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W74
T14675 BMS-564929 BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropi
T14843 Bifluranol Bifluranol is an anti-androgen.
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T15749 LGD-2226 LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporo
T15816 LY341495 LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
T1596 Chlormadinone acetate Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
T19449 N-desmethyl Enzalutamide D6 N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
T19450 N-desmethyl Enzalutamide N-desmethyl Enzalutamide is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacody
T2108 Andarine Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2207 Adrenosterone Adrenosterone is a steroid hormone isolated from the adrenal cortex.
T2236 RU58841 RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
T2339 Apalutamide Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T2408 Ostarine Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintain
T2991 3,3'-Diindolylmethane DIM (3, 3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
T3017 Trenbolone acetate Trenbolone acetate is a synthetic androgen steroid with anabolic properties.
T3137 Parenabol Boldenone undecylenate is a synthetic steroid.
T3357 17 alpha-propionate 17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
T3393 Triptophenolide Triptophenolide is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
T3618 GSK2881078 GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their phys
T4357 LGD3303 LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
T4358 Testolone RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
T6002 Enzalutamide Enzalutamide (MDV 3100) is a non-steroidal androgen receptor (AR) antagonist (IC50: 36 nM in LNCaP prostate cells).
T6400 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
T6509 Galeterone Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct m
T6829 EPI001 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
T6889 MI136 MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T6915 Darolutamide ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
T7040 Angiotensin II human Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I convert Angiotensin II
T7358 YK11 YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentratio
T7440 4,4'-DDE 4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T7690 2-hydroxy Flutamide 2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
T8217 Enzalutamide carboxylic acid Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
T8592 CTK8A3536 CTK8A3536 is an inhibitor of Androgen receptor.
T8709 Nandrolone phenpropionate Nandrolone phenpropionate is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis
TCS1372 Atraric acid Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It
TMA1012 Ganoderiol F Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with I
TN1061 Ganoderol B Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and beni
TN1067 6'-O-Galloyl paeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1663 Ganoderic acid DM Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this supp
TN2245 Sunset yellow Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care must be taken when usin
TN2252 Syrosingopine Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth thro
TQ0209 Ailanthone Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309 nM).
TQ0214 Dimethylcurcumin Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.
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