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Adenosine Receptor
T0070 Pentoxifylline Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rh
T1368 Methyl protocatechuate Thermographic recording material with improved image tone.
T1825 Reversine Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
T2205 Theophylline-7-acetic acid Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical pre
T2373 Vipadenant Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
T2671 Regadenoson Regadenoson is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and a
T6115 Fostamatinib Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T6441 CGS 21680 HCl CGS 21680 HCl( IC50=22 nM),an adenosine receptor agonist, exhibits 140-fold potency in A2 receptor over A1 receptor.
T6552 Istradefylline Istradefylline(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails. It has been used in trials studying the treatmen
T6979 SCH58261 SCH 58261 is a potent and selective A2a adenosine receptor antagonist.The Ki =2.3 nM for rat A2a and 2 nM is for bovine A2a.
T7021 ZM241385 ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
T4265 AZD4635 AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
T4290 Preladenant Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Ki: 1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
T6884 2-Cl-IB-MECA 2-Cl-IB-MECA is an adenosine A3 receptor agonist.
T7183 CPI-444 CPI-444 is an antagonist of the adenosine A2A receptor.It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer.
T7188 Piclidenoson Piclidenoson, a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
T7320 Tozadenant Tozadenant is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)
T7509 PD 117519 PD 117519 is an agonist of adenosine receptor
T7683 Adenosine amine congener Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor,.
TQ0125 Capadenoson Capadenoson is a selective adenosine-A1 receptor agonist.
TQ0136 GR 79236 GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.
T8312 Derenofylline Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM)
T14078 AB928 AB928 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. It has immunomodulatory activity[1].
T14944 CGS 15943 CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2
T13008 ST3932 ST3932 is a ST1535 metabolite, is a adenosine A2A receptor antagonist(Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively).
T11762 Kira8 Hydrochloride Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
T16158 PF-02575799 PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).
T16159 Muramyl dipeptide Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly de
T16281 Nelonicline Nelonicline is a selective agonist of neuronal nicotinic receptors.
T8598 CHEMBL241987 CHEMBL241987 targets the Adenosine receptor A3 (human)
T8613 1-Ethyl-6-aminouracil 1-Ethyl-6-aminouracil is an intermediate in the synthesis of a series of new substituted Xanthines which have high affinity and selectivity for the human adenosine A2B receptors.
T8512 BAY-545 BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
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