||2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofuran is a member of
||Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and
||4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin). 4-Hydroxycoumar
||Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydr
||Primidone is an anticonvulsant of the pyrimidinedione class.
||Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
||In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica tree.
||Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD and FAD, and protei
||Adiphenine hydrochloride, a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
||Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti
||Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
||Ipratropium bromide monohydrate
||Ipratropium bromide is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial d
||Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.
||Dipivefrin that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
||Solifenacin succinate is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INC
||Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
||Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
||Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation a
||Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though
||Pancuronium dibromide, a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide blocking neuromuscular transmission is achieved by c
||Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect
||Homatropine Hydrobromide is the hydrobromide salt form of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine, a competitive inhibitor of a
||Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics an
||Rivastigmine is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
||Azatadine dimaleate is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.
||Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
||Dextromethorphan HBr monohydrate
||Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (recept
||Lobeline hydrochloride is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
||Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
||Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barri
||Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.
||Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
||Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
||Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
||Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
||Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagon
||Atropine sulfate monohydrate
||Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
||Atropine sulfate is a competitive antagonist for muscarinic acetylcholine receptor.
||Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
||Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
||Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
||Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacol
||Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold.
||Cytisine, an alkaloid, is found naturally in several plants.
||Diphemanil methylsulfate, a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva
||3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
||Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most
||Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
||Flavoxate Hydrochloride(DW-61 Hydrochloride), a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
||Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
||Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
||Gallamine Triethiodide, a synthetic inhibiting drug, is nondepolarizing.
||DEET is the most general active composition in insect repellents.
||Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that c
||Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed be
||Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the
||Clidinium, a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointes
||Carbaryl is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a par
||Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
||Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi
||Pilocarpine hydrochloride, a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
||Decamethonium Bromide is a neuromuscular blocker and nicotinic AChR partial agonist.
||Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
||Adenosine 5'-monophosphate monohydrate
||Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP
||Diphenidol hydrochloride, a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
||Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macropha
||L-Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bron
||Propoxur is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholin
||Temefos is a cholinesterase inhibitor. Temefos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects including midges, mosquito
||Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not
||A2B receptor antagonist 1
||A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1.
||Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propanthel
||Choline chloride is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various me
||Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholi
||Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
||Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
||Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.
||CDD0102 is a potent agonist of M1 Muscarinic receptor.
||Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylli
||Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline
||Cyclone hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
||Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
||Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve agents) in combination
||Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor ant
||Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to tr
||Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.
||Metixene hydrochloride is an anticholinergic antiparkinsonian agent.
||MRS-3777 hemioxalate is a selective antagonist of adenosine A3 receptor .
||N-0861 racemate is the racemate of N-0861.
||Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine
||APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent and non-selective agonist of A3 adenosine receptor.
||NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).
||Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimics the parasympatho
||Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity,
||Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
||Phenserine is a derivative of Physostigmine and is annoncompetitive, long-acting and selective inhibitor of AChE.
||Pipecuronium bromide is a powerful competitive antagonist of nAChR(Kd of 3.06 μM).
||Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative
||RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.
||Tropicamide is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks
||Timepidium bromide is an agent of anticholinergic.
||Sch412348 is a potent competitive the human adenosine A2A receptor antagonist with Ki of 0.6 nM and has >1000-fold selectivity over all other adenosine receptors.
||TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
||Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ilea
||A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act
||UP202-56 is an adenosinergic agonist and is an adenosine analog.
||Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres
||DL-trihexyphenidyl hydrochloride is a muscarinic antagonist.
||Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxidant and antibacter
||YM17E is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor(IC50 of 44 nM in rabbit liver microsomes in vitro).
||Nortropine is used as muscarinic receptor antagonists.
||GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.
||MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).
||Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and re
||Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric
||Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and i
||Bambuterol, a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
||Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
||Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
||Trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium has not been implicated in causing liver enzyme
||Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
||Fesoterodine Fumarate is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodin
||Perindoprilat is an angiotensin-converting enzyme inhibitor.
||Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
||Darifenacin is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
||Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is
||Pirenzepine dihydrochloride is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
||Itopride hydrochloride is an AChE and D2DR inhibitor.
||KFM19 is an effective and selective antagonist of the Adenosine receptor (A1-receptor) (IC50: 50 nM).
||Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
||Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
||Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.
||Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
||Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neos
||Rivastigmine tartrate is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHE
||Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.
||Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
||Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
||Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively a
||Varenicline tartrate is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.
||Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
||Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably sl
||Taminadenant is an adenosine receptor antagonist.
||(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.
||(+)-Phenserine is a novel selective inhibitor of cholinesterase non-competitive (IC50: 45.3 μM).
||TBPB is an allosteric M1 mAChR agonist.
||1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythroc
||α-Muricholic acid is the most abundant primary bile acid in rodents.
||Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
||Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
||6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
||SQ 22536, the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated
||Scopolamine N-oxide HBr
||Scopolamine N-oxide HBr is an antagonist of the muscarinic acetylcholine.
||Scopolamine HBr trihydrate
||Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE but may hav
||Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
||Tacrine hydrochloride hydrate
||Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory
||Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
||A 582941 is a Selective agonist of α7 nAChR partial
||Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
||EVP-6124 hydrochloride is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
||Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by wh
||BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
||Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
||Cevimeline hydrochloride hemihydrate
||Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
||PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
||Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been impl
||Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
||Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of c
||GTS 21 dihydrochloride
||GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
||Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may ha
||Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scave
||Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
||Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
||Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
||Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
||Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
||Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce
||1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
||Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
||Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been wid
||Bethanechol chloride is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract followin
||GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
||Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
||MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein
||VU 0357017 hydrochloride
||VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
||Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Tebanicline is an eff
||Tebanicline (ABT-594, Ebanicline), is an effective synthetic nicotinic (non-opioid) analgesic drug.
||Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT
||Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due
||Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic aci
||β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and
||Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
||BQCA a highly selective allosteric modulator of the M1 mAChR.
||1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can increase acetylcholine
||1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes m
||Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
||Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.
||Fmoc-Val-Ala-PAB is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-pac
||Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).
||Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the
||Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respec
||ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
||Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can reg
||Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
||Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
||Umeclidinium bromide is a novel mAChR antagonist.
||Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and chol
||Hyoscyamine sulfate hydrate
||Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa bellad
||Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
||Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor
||Adenine hydrochloride hydrate
||Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine
||MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.
||mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
||mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
||Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
||Norarecoline hydrochloride is a muscarinic agonist.
||Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalyt
||Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.
||1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treat
||1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
||1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/A
||Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
||5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
||Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on g
||Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to an
||Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
||Ipratropium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
||Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
||LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
||Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
||Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
||Succinylcholine Chloride Dihydrate
||Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
||Tiotropium Bromide hydrate
||Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor ant
||Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
||Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
||5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK
||PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
||1. Corynoline is an acetylcholinesterase inhibitor.
||Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
||Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alz
||Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin bio
||Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
||Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism of action involves
||Encenicline is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.
||Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca). Anabasine has been used as an industrial insecticide and, since it is present in trace
||NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.
||Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
||Piperidolate inhibits intestinal cramp induced by acetylcholine
||CCMI is a potent and selective modulator of α7 nAChR-positive allosteric.
||4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activities.
||Isoxazole is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.
||Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).
||Benzetimide hydrochloride is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.
||Coluracetam(MKC-231) is a Choline Uptake Enhancer.
||Aldicarb sulfone is a cholinesterase inhibitor .
||PNU-282987 S enantiomer free base
||PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).
||2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)
||AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
||CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
||Pachycarpine is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
||NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
||Syn-Ake acetate is a muscarinic acetylcholine receptor antagonist.
||EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
||VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
||Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
||VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
||VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
||Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM
||BNC210 is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
||Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
||BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
||PSEM 89S TFA
||PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
||TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
||A 582941 HCl (848591-90-2(free base))
||A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
||A 582941 HCl (848591-90-2(free base))
||A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
||Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids
||4BP-TQS is an allosteric agonist of α7 nAChRs.
||Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing.
||N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal ac
||Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavengin
||Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
||3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic ac
||6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04
||(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Strep
||Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
||Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activity in a dose-depend
||Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur
||Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
||Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apop
||Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
||Garcinone C is a potent inhibitor of AChE.
||Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurot
||Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentati
||Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
||Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (ACh
||Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
||Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
||Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
||Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
||Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
||Questin has promising inhibitory potential against AChE, BChE, and BACE1, it may be used in the development of therapeutic or preventive agents for Alzheimer's disease.
||1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase act
||1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
||7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
||8-Hydroxypinoresinol has antioxidant activity,it and phillygenin significantly reduce the cell injury by 3-morpholinosydnonimine (SIN-1), a ONOO- generator, may be useful for the t
||8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows
||Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to gene
||Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activi
||beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-glucosidase inhibitory ac
||Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
||Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
||Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion gen
||Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows signific
||Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory activity with the IC
||Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the
||Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0
||Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the per
||Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 valu
||Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoprotein
||Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carc
||(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
||Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
||Tubotaiwine shows selective activity against L. infantum. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have in-vivo analgesic a
||A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
||Metixene hydrochloride hydrate
||Metixene is an anticholinergic antiparkinsonian agent, potently inhibits the binding of quinuclidinyl to the muscarinic receptor in rat brain cortical tissue (IC50: 55 nM, Kd: 15 n