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AChR
Fr14127 2,3-Dihydrobenzofuran 2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofuran is a member of
Fr16605 Lupinine Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and
PDK0015 4-Hydroxycoumarin 4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin). 4-Hydroxycoumar
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydr
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0052L Strychnine Sulfate In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica tree.
T0064 Adenine Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD and FAD, and protei
T0072 Adiphenine hydrochloride Adiphenine hydrochloride, a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti
T0086 Galanthamine HBr Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T0098 Ipratropium bromide monohydrate Ipratropium bromide is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial d
T0099 Tolterodine tartrate Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.
T0103 Dipivefrin hydrochloride Dipivefrin that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
T0111 Solifenacin succinate Solifenacin succinate is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INC
T0113 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T0130 Physostigmine Salicylate Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
T0156 Rocuronium bromide Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation a
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though
T0166 Pancuronium bromide Pancuronium dibromide, a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide blocking neuromuscular transmission is achieved by c
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect
T0177 Homatropine Bromide Homatropine Hydrobromide is the hydrobromide salt form of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine, a competitive inhibitor of a
T0185 Escitalopram Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics an
T0229 Rivastigmine Rivastigmine is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
T0236 Azatadine Maleate Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T0253 Methscopolamine Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
T0262 Dextromethorphan HBr monohydrate Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (recept
T0268 Lobeline hydrochloride Lobeline hydrochloride is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
T0269 Dichlorisone Acetate Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
T0287 Hexamethonium Bromide Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barri
T0296 Pempidine Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T0364L Dibucaine hydrochloride Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0375 Atropine Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagon
T0375L Atropine sulfate monohydrate Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
T0375L2 Atropine sulfate Atropine sulfate is a competitive antagonist for muscarinic acetylcholine receptor.
T0401 Benzethonium chloride Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
T0427 Homatropine Methylbromide Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0455 Clozapine Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacol
T0464 Carbetapentane citrate Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold.
T0479 Cytisine Cytisine, an alkaloid, is found naturally in several plants.
T0594 Diphemanil mesylate Diphemanil methylsulfate, a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva
T0625 Theobromine 3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
T0665 2,6-Dihydroxypurine Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0703 Flavoxate hydrochloride Flavoxate Hydrochloride(DW-61 Hydrochloride), a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
T0713 Drofenine hydrochloride Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T0720 Gallamine triethiodide Gallamine Triethiodide, a synthetic inhibiting drug, is nondepolarizing.
T0731 N,N-Diethyl-m-toluamide DEET is the most general active composition in insect repellents.
T0765 4-Methylpyrazole Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that c
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed be
T0780 Mestinon Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the
T0786 Clidinium bromide Clidinium, a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointes
T0790 Carbaryl Carbaryl is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a par
T0794 Mepenzolate Bromide Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi
T0804 (+)-Pilocarpine hydrochloride Pilocarpine hydrochloride, a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
T0818 Decamethonium bromide Decamethonium Bromide is a neuromuscular blocker and nicotinic AChR partial agonist.
T0851 Pregnenolone Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T0853L Adenosine 5'-monophosphate monohydrate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP
T0862 Diphenidol hydrochloride Diphenidol hydrochloride, a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
T0944 Levamisole hydrochloride Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macropha
T0962 L-Hyoscyamine L-Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bron
T0976 Propoxur Propoxur is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholin
T0997 Temephos Temefos is a cholinesterase inhibitor. Temefos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects including midges, mosquito
T0999 Clevidipine butyrate Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not
T10058 A2B receptor antagonist 1 A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1.
T1006 Propantheline bromide Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propanthel
T1039 Choline chloride Choline chloride is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various me
T1049 Oxybutynin hydrochloride Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholi
T1049L Oxybutynin Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T1072 Loxeen Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.
T10731 CDD0102 CDD0102 is a potent agonist of M1 Muscarinic receptor.
T1083 Theophylline Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylli
T1083L Theophylline monohydrate Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline
T10914 Cyclodrine hydrochloride Cyclone hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
T11004 Desformylflustrabromine hydrochloride Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
T1111 Pralidoxime Chloride Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve agents) in combination
T11366 Garcinol
T1179 Tiotropium bromide Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor ant
T1199 Mitotan Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to tr
T1202 (-)-Cotinine Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.
T12020 Metixene hydrochloride Metixene hydrochloride is an anticholinergic antiparkinsonian agent.
T12107 MRS-3777 hemioxalate MRS-3777 hemioxalate is a selective antagonist of adenosine A3 receptor .
T12136 N-0861 racemate N-0861 racemate is the racemate of N-0861.
T1215 Nicardipine hydrochloride Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine
T12159 APNEA APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent and non-selective agonist of A3 adenosine receptor.
T12191 NBTGR NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).
T1221 Acetylcholine chloride Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimics the parasympatho
T1229 Erdosteine Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity,
T1231 Pilocarpine nitrate Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
T12446 Phenserine Phenserine is a derivative of Physostigmine and is annoncompetitive, long-acting and selective inhibitor of AChE.
T12481 Pipecuronium bromide Pipecuronium bromide is a powerful competitive antagonist of nAChR(Kd of 3.06 μM).
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative
T12766 RPR121056 RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.
T1281 Tropicamide Tropicamide is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks
T12825 Timepidium bromide Timepidium bromide is an agent of anticholinergic.
T12868 Sch412348 Sch412348 is a potent competitive the human adenosine A2A receptor antagonist with Ki of 0.6 nM and has >1000-fold selectivity over all other adenosine receptors.
T13066 TAK-071 TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
T13129 Terodiline hydrochloride Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ilea
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act
T13256 UP202-56 UP202-56 is an adenosinergic agonist and is an adenosine analog.
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres
T1328 DL-trihexyphenidyl hydrochloride DL-trihexyphenidyl hydrochloride is a muscarinic antagonist.
T13301 Violanthin Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxidant and antibacter
T13373 YM17E YM17E is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor(IC50 of 44 nM in rabbit liver microsomes in vitro).
T1341 Nortropine Nortropine is used as muscarinic receptor antagonists.
T13713 GP531 GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.
T13772 MHP 133 MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).
T14094 Acetamiprid Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and re
T14140 Agaric acid Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric
T14333 Asoxime dichloride Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and i
T1446 Bambuterol hydrochloride Bambuterol, a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
T1459 Cisatracurium besylate Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
T1460 Dicyclomine hydrochloride Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
T1472 Trospium chloride Trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium has not been implicated in causing liver enzyme
T1474 Otilonium bromide Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
T1475 Fesoterodine fumarate Fesoterodine Fumarate is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodin
T1484 Perindoprilat Perindoprilat is an angiotensin-converting enzyme inhibitor.
T14966 Cimetropium Bromide Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
T1534 Darifenacin HBr Darifenacin is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is
T1542 Pirenzepine dihydrochloride Pirenzepine dihydrochloride is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
T1552 Itopride hydrochloride Itopride hydrochloride is an AChE and D2DR inhibitor.
T15655 KFM19 KFM19 is an effective and selective antagonist of the Adenosine receptor (A1-receptor) (IC50: 50 nM).
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1575 Nizatidine Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T1594 Vecuronium bromide Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.
T1612 Hodostin Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
T1624 Neostigmine bromide Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neos
T1628 Rivastigmine tartrate Rivastigmine tartrate is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHE
T16353 Meseclazone Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.
T1636 Paroxetine hydrochloride Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T16417 Oxitropium Bromide Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
T16563 Pozanicline Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively a
T1657 Varenicline Tartrate Varenicline tartrate is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.
T1668 Vinblastine sulfate Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T1682 Methacholine Chloride Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably sl
T16980 Taminadenant Taminadenant is an adenosine receptor antagonist.
T17300 (-)-(S)-B-973B (-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.
T17312 (+)-Phenserine (+)-Phenserine is a novel selective inhibitor of cholinesterase non-competitive (IC50: 45.3 μM).
T1760 TBPB TBPB is an allosteric M1 mAChR agonist.
T19084 1-Naphthyl acetate 1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythroc
T19623 α-Muricholic acid α-Muricholic acid is the most abundant primary bile acid in rodents.
T2138 Oxyphencyclimine Hydrochloride Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
T2141 Mecamylamine hydrochloride Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
T21532 6-beta-Hydroxyhyoscyamine 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
T2172 SQ 22536 SQ 22536, the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated
T2181 Scopolamine N-oxide HBr Scopolamine N-oxide HBr is an antagonist of the muscarinic acetylcholine.
T2182 Scopolamine HBr trihydrate Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE but may hav
T2183 Scopolamine butylbromide Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
T2191 Tacrine hydrochloride hydrate Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory
T2198 Arecoline HBr Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
T22016 A 582941 A 582941 is a Selective agonist of α7 nAChR partial
T22448 Tropisetron Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
T2285 EVP-6124 hydrochloride EVP-6124 hydrochloride is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
T2319 Acotiamide hydrochloride Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by wh
T2337 BMS303141 BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T2387 Glycopyrrolate Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
T2390 Cevimeline hydrochloride hemihydrate Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
T2422 PNU 282987 PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
T2555 Aclidinium bromide Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been impl
T2558 Cladribine Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
T2571 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of c
T2663 GTS 21 dihydrochloride GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
T2725 Scopolamine HBr Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may ha
T2759 Loganin Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scave
T2782 Catharanthine Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2846 Isoimperatorin Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T2939 Forskolin Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T2984 Scopoletin Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
T2S0820 Karanjin Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce
T2S1181 Aloenin A 1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
T3023 Catharanthine sulfate Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
T3026 (-)-Huperzine A Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been wid
T3126 Bethanechol chloride Bethanechol chloride is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract followin
T3196 GNF7 GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
T3324 Lycorine Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T3503 MC-Val-Cit-PABC-PNP MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein
T3619 VU 0357017 hydrochloride VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
T3694 Tebanicline Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Tebanicline is an eff
T3720 Tebanicline hydrochloride Tebanicline (ABT-594, Ebanicline), is an effective synthetic nicotinic (non-opioid) analgesic drug.
T3767 Polygalacic acid Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT
T3791 Atractyloside A Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due
T3819 Acetylursolic acid Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic aci
T3865 beta-Eudesmol β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and
T3872 Nodakenin Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
T3993 BQCA BQCA a highly selective allosteric modulator of the M1 mAChR.
T3S0478 Scopolamine 1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can increase acetylcholine
T3S1612 kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes m
T4006 Pentostatin Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
T4246 Varenicline Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.
T4286 Fmoc-Val-Ala-PAB Fmoc-Val-Ala-PAB is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-pac
T4289 Mc-Val-Ala-PAB Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).
T4439 Choline glycerophosphate Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the
T4466 Pitofenone hydrochloride Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respec
T4668 ABT-702 dihydrochloride ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
T4960 VASICINE Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can reg
T4981 Anisotropine Methylbromide Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T4986 Imidafenacin Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
T4997 Umeclidinium bromide Umeclidinium bromide is a novel mAChR antagonist.
T4S0111 Hupehenine Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and chol
T4S1619 Hyoscyamine sulfate hydrate Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa bellad
T4S1725 Galanthamine Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
T5051 Isopropamide Iodide Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor
T5081 Adenine hydrochloride hydrate Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine
T5149 MC-Val-Cit-PAB MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.
T5476 mAChr-in-1 mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
T5655 mAChR-IN-1 hydrochloride mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
T5721 Dehydroevodiamine hydrochloride Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
T5805 Norarecoline hydrochloride Norarecoline hydrochloride is a muscarinic agonist.
T5855 Edrophonium chloride Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalyt
T5940 Proxyphylline Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.
T5S0802 Palmatine 1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treat
T5S1025 Picfeltarraenin IA 1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T5S2361 Epiberberine 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/A
T6115 Fostamatinib Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T6364 Desfesoterodine 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
T6397 Atracurium besylate Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on g
T6426 Buclizine HCl Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to an
T6478 Donepezil HCl Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T6547 Ipratropium Bromide Ipratropium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
T6548 Irsogladine Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
T6575 LY2119620 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
T6607 Nitenpyram Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
T6618 Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T6684 Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
T6707 Tiotropium Bromide hydrate Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor ant
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6744 Methylbenactyzine Bromide Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T6745 5-Iodotubercidin 5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK
T6950 PNU120596 PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
T6S2356 (+)-Corynoline 1. Corynoline is an acetylcholinesterase inhibitor.
T7002 Trihexyphenidyl hydrochloride Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
T7041 Donepezil Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alz
T7052 Gnetol Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin bio
T7114 GALANTHAMINONE Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
T7124 Dinotefuran Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism of action involves
T7193 Encenicline Encenicline is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.
T7224 (-)-Anabasine Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca). Anabasine has been used as an industrial insecticide and, since it is present in trace
T7340 NECA NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.
T7392 Revefenacin Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
T7405 Piperidolate Piperidolate inhibits intestinal cramp induced by acetylcholine
T7422 CCMI CCMI is a potent and selective modulator of α7 nAChR-positive allosteric.
T7465 4-Methylbenzylidene camphor 4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activities.
T7500 Isoxazole Isoxazole is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.
T7555 Piperidolate hydrochloride Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).
T7561 Benzetimide hydrochloride Benzetimide hydrochloride is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.
T7591 Coluracetam Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7640 Aldicarb sulfone Aldicarb sulfone is a cholinesterase inhibitor .
T7695 PNU-282987 S enantiomer free base PNU-282987 S enantiomer free base is an  agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).
T7736 2-Chloroadenosine 2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)
T7780 AVex-73 AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
T7813 CZEN-002 CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T7853 Pachycarpine Pachycarpine is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
T7884 NS 1738 NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
T7895 Syn-Ake acetate Syn-Ake acetate is a muscarinic acetylcholine receptor antagonist.
T7955 EB-3D EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T8007 VU0238429 VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
T8193 Thujone Thujone is an inhibitor of  ACh with an IC50 value of 24.7μM.
T8219 VU0238441 VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
T8224 VU0119498 VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
T8306 Epiberberine (chloride) Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM
T8318 BNC210 BNC210 is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
T8383 Cyclopentolate Hydrochloride Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
T8512 BAY-545 BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
T8552 PSEM 89S TFA PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
T8585 TA-03 TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
T8725 A 582941 HCl (848591-90-2(free base)) A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T8725 A 582941 HCl (848591-90-2(free base)) A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T8770 Harmalol Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids
T8868 4BP-TQS 4BP-TQS is an allosteric agonist of α7 nAChRs.
TL0018 Lobelin Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing.
TN1030 N-p-trans-Coumaroyltyramine N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal ac
TN1037 Groenlandicine Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavengin
TN1091 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
TN1248 3-Epioleanolic acid 3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic ac
TN1305 6-Ethoxydihydrosanguinarine 6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04
TN1409 Asimilobine (-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Strep
TN1472 Cassiaside Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
TN1527 Corynoxidine Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activity in a dose-depend
TN1544 D-Menthol Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur
TN1559 Dehydrodicentrine Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
TN1645 Flavokawain C Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apop
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1673 Garcinone C Garcinone C is a potent inhibitor of AChE.
TN1736 Hibifolin Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurot
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentati
TN1799 Isorubrofusarin 10-gentiobioside Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
TN1848 Kuwanon E Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (ACh
TN1858 Leptomerine Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
TN1899 Lycoramine Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN1899 Lycoramine Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN2067 Picfeltarraenin X Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
TN2100 Pratensein Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
TN2131 Questin Questin has promising inhibitory potential against AChE, BChE, and BACE1, it may be used in the development of therapeutic or preventive agents for Alzheimer's disease.
TN2504 1,5-Dihydroxyxanthone 1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase act
TN2505 1,5-Diphenylpentan-1-one 1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
TN3243 7-O-Methyleriodictyol 7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
TN3285 8-Hydroxypinoresinol 8-Hydroxypinoresinol has antioxidant activity,it and phillygenin significantly reduce the cell injury by 3-morpholinosydnonimine (SIN-1), a ONOO- generator, may be useful for the t
TN3287 8-Lavandulylkaempferol 8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows
TN3380 Alloisoimperatorin Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to gene
TN3466 Atherosperminine Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activi
TN3500 beta-Amyrone beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-glucosidase inhibitory ac
TN3550 Buxbodine B Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
TN3696 Conodurine Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
TN3744 Cyclomorusin Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion gen
TN3812 Dehydrovomifoliol Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows signific
TN3875 Dipterocarpol Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory activity with the IC
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the
TN4426 Leojaponin Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0
TN4456 Lucidadiol Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the per
TN4492 Mangostanol Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 valu
TN4600 Myrianthic acid Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoprotein
TN4652 Niazimicin Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carc
TN4812 Pluviatolide (-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
TN4837 Pseudotaraxasterol Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
TN5193 Tubotaiwine Tubotaiwine shows selective activity against L. infantum. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have in-vivo analgesic a
TQ0117 A-867744 A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
TQ0304 Metixene hydrochloride hydrate Metixene is an anticholinergic antiparkinsonian agent, potently inhibits the binding of quinuclidinyl to the muscarinic receptor in rat brain cortical tissue (IC50: 55 nM, Kd: 15 n
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