T0025 |
Haloperidol |
Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromaz |
T0031 |
Ziprasidone hydrochloride monohydrate |
Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
T0031L |
Ziprasidone hydrochloride |
Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
T0031L2 |
Ziprasidone |
Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme |
T0039 |
Dapoxetine |
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. |
T0074 |
Chlorprothixene |
Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized. |
T0074L |
Chlorprothixene hydrochloride |
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti |
T0076 |
Paliperidone |
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabo |
T0081 |
Lafutidine |
Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion. |
T0088 |
Urapidil hydrochloride |
Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. |
T0113 |
Mebhydrolin napadisylate |
Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis. |
T0137 |
Mirtazapine |
Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminot |
T0162 |
Quetiapin |
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though |
T0165 |
Urapidil |
Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. |
T0172 |
Maprotiline hydrochloride |
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect |
T0174 |
Cyproheptadine hydrochloride |
Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2. |
T0203 |
Sumatriptan succinate |
Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. |
T0204 |
Protriptyline hydrochloride |
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride blocks the re- |
T0205 |
Brompheniramine hydrogen maleate |
Brompheniramine maleate is an antagonist against histamine H1 receptors. |
T0216 |
Eletriptan HBr |
Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor. |
T0217 |
Levodropropizine |
Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug. |
T0225 |
Pizotifen Malate |
Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane. |
T0236 |
Azatadine Maleate |
Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM). |
T0255 |
Clomipramine hydrochloride |
Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastr |
T0302 |
Triflupromazine hydrochloride |
Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists. |
T0318 |
Ataractan |
Azacyclonol is a drug used to diminish hallucinations in psychotic individuals. |
T0333 |
Aniracetam |
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR. |
T0338 |
Minaprine dihydrochloride |
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states. |
T0351 |
Risperidal |
Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
T0365 |
Thioridazine hydrochloride |
Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. |
T0370 |
Pheniramine maleate |
Pheniramine Maleate,an alkylamine derivative with antihistaminic and vasodilatory properties,binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production |
T0428 |
Alverine citrate |
Alverine Citrate is utilized in functional gastrointestinal disorders. |
T0445 |
Promethazine |
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) . |
T0450 |
Fluoxetine |
Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres |
T0450L |
Fluoxetine hydrochloride |
Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres |
T0472 |
Venlafaxine hydrochloride |
Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSI |
T0482 |
Sertraline hydrochloride |
Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
T0525 |
Flopropione |
Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
T0647 |
Tryptamine |
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace a |
T0663 |
2-Bromo-6-methoxynaphthalene |
2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction. |
T0678 |
Amitriptyline hydrochloride |
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
T0680 |
Lamotrigine |
Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
T0716 |
Molindone hydrochloride |
Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain. |
T0723 |
Cloperastine hydrochloride |
Cloperastine hydrochloride is a type of flavonoid. |
T0766 |
Promazine hydrochloride |
Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed be |
T0783 |
Mianserin hydrochloride |
Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may ca |
T0785 |
Dexchlorpheniramine Maleate |
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmaco |
T0802 |
Procaine hydrochloride |
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi |
T0811 |
Amisulpride |
Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia |
T0869 |
Atomoxetine hydrochloride |
Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cogni |
T0965 |
Histamine |
Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, a |
T0991 |
Desipramine hydrochloride |
Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochl |
T1042 |
Granisetron hydrochloride |
Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients. |
T1045 |
Trimipramine maleate |
Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its acti |
T1066 |
Ketanserin |
Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. |
T1069 |
Metoclopramide hydrochloride |
Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic. |
T1077 |
Fluvoxamine maleate |
Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders. |
T1081 |
Nafronyl oxalate |
Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It ma |
T1092 |
Zolmitriptan |
Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerv |
T1156 |
Palonosetron hydrochloride |
Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
T1170 |
Olopatadine hydrochloride |
Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS. |
T1173 |
Tropisetron hydrochloride |
Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinausean |
T1180 |
Blonanserin |
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side e |
T1266 |
Terfenadine |
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative |
T1279 |
Vilazodone |
Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits th |
T1291 |
Cisapride |
Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase |
T1327 |
Nortriptyline hydrochloride |
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres |
T1354 |
N-Acetyl-5-hydroxytryptamine |
N-Acetylserotonin (NAS), also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is co |
T1384 |
Chlorpromazine hydrochloride |
Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due t |
T1412 |
Loxapine succinate salt |
Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia. |
T1442 |
Pizotifen |
Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating pr |
T1445 |
Agomelatine |
Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an |
T1471 |
Duloxetine hydrochloride |
Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLY |
T1478 |
Ondansetron hydrochloride |
Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, inc |
T1483 |
Citalopram HBr |
Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central |
T1509 |
Cyclobenzaprine hydrochloride |
Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms. |
T1512 |
Rizatriptan benzoate |
Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches. |
T1528 |
Azasetron hydrochloride |
Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic. |
T1540 |
Doxepin hydrochloride |
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is |
T1551 |
Tegaserod maleate |
Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United Sta |
T1566 |
Aripiprazole |
Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, |
T1567 |
Olanzapine |
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
T1580 |
Desvenlafaxine |
Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an ant |
T1619 |
Trazodone hydrochloride |
Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and o |
T1636 |
Paroxetine hydrochloride |
Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. |
T1644 |
Dopamine hydrochloride |
Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- an |
T1735 |
Lurasidone hydrochloride |
Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, seroton |
T1769 |
Pardoprunox |
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early |
T1774 |
SB 742457 |
SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease. |
T1951 |
Asenapine Maleate |
Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bi |
T2076 |
Pimavanserin |
Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic |
T2092 |
Amitifadine hydrochloride |
Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
T2132 |
Buspirone hydrochloride |
Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). |
T2190 |
Methiothepin mesylate |
Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic. |
T2209 |
Serotonin hydrochloride |
Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS,and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
T2278 |
Piboserod |
Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist. |
T2289 |
RU 24969 hemisuccinate |
RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors. |
T2306 |
Brexpiprazole |
Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
T2317 |
Almotriptan Malate |
Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults. |
T2344 |
LY344864 |
LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
T2395 |
Vortioxetine |
Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations durin |
T2395L |
Vortioxetine HBr |
Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM). |
T2402 |
Tianeptine sodium |
Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes. |
T2428 |
TG6-10-1 |
TG6-10-1 is an EP2 antagonist. |
T2459 |
BRL54443 |
BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively). |
T2525 |
Alosetron hydrochloride |
Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in t |
T2542 |
Prucalopride |
Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. |
T2565 |
Hesperetin |
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. |
T2589 |
Dalasetron Mesylate Hydrate |
Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiot |
T2599 |
Pirenperone |
Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action. |
T2631 |
WAY-100635 Maleate |
WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). |
T2688 |
LY310762 |
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
T2714 |
Rotundine |
Rotundine is extracted from Corydalis yanhusuo W. T. Wang. |
T2874 |
Tetrahydroberberine THB |
Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors. |
T3046 |
BMY 7378 dihydrochloride |
BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor. |
T3085 |
Piperacetazine |
Piperacetazine, an antipsychotic prodrug, is used forschizophrenia. |
T3179 |
Eptapirone |
F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential. |
T3269 |
Metadoxine |
Metadoxine is a neurotransmitter stimulant. |
T3275 |
Nefazodone hydrochloride |
Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. |
T3341 |
Elemicin |
Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human. |
T3369 |
Nuciferine |
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
T3431 |
Pardoprunox hydrochloride |
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist a |
T3453 |
WAY-100635 maleate salt |
WAY-100635 maleate is a effective and elective 5-hydroxytryptamine1A antagonist ( IC50=0.95 ± 0.12 nM). |
T3526 |
Dasotraline hydrochloride |
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, a |
T3648 |
YL0919 |
YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor. |
T3704 |
Lasmiditan |
Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed |
T4008 |
Metergoline |
Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy. |
T6188 |
Desvenlafaxine succinate hydrate |
Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI). |
T6232 |
Vilazodone HCl |
Vilazodone HCl,a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder. |
T6241 |
Quetiapine Fumarate |
Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
T6423 |
BRL-15572 dihydrochloride |
BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. |
T6426 |
Buclizine HCl |
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to an |
T6461 |
Dapoxetine HCl |
Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation. |
T6488 |
Epinastine HCl |
Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
T6493 |
Escitalopram Oxalate |
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
T6562 |
Latrepirdine |
Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
T6597 |
Mosapride Citrate |
Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist. |
T6600 |
Naftopidil DiHCl |
Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
T6602 |
Naratriptan hydrochloride |
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Nar |
T6615 |
Ondansetron |
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
T6616 |
Ondansetron HCl |
Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. |
T6655 |
SB269970 HCl |
SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors. |
T6728 |
VUF 10166 |
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
T6814 |
Cyproheptadine HCl |
Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
T6946 |
Pimavanserin tartrate |
Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson’s disease. |
T6958 |
Prucalopride Succinate |
Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively. |
T6959 |
PRX-08066 Maleic acid |
PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2. |
T6973 |
RS127445 |
RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. |
T4305 |
8-OH-Dpat |
8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. |
T4266 |
LY 334370 |
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM |
T4297 |
Flibanserin |
Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevat |
T4118 |
SB 271046 hydrochloride |
SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, |
T2226 |
Pergolide mesylate salt |
PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEAR |
T4568 |
Dolasetron |
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
T4562 |
Ramosetron |
Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st gene |
T4577 |
Cariprazine |
Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A recepto |
T4560 |
Alprenolol |
Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
T4576 |
Perospirone |
Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
T4978 |
Sarpogrelate hydrochloride |
Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is |
T5179 |
AVN492 |
AVN-492 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM). |
T5158 |
N-Desmethylclozapine |
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid recepto |
T5336 |
Zacopride hydrochloride |
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. |
T5387 |
LP-211 |
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor. |
T5380 |
Ansofaxine hydrochloride |
Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively). |
T5389 |
Volinanserin |
Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 |
T5271 |
5-Methoxytryptamine |
5-Methoxytryptamine, nonselective serotonin receptor agonist that lacks affinity for the 5-HT3 receptor. |
T5858 |
Sertindole |
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, re |
T7103 |
idalopirdine |
Idalopirdine, a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease. |
T7135 |
Phenylbiguanide |
Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM) |
T7277 |
SB 242084 dihydrochloride hydrate |
SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor. |
T7281 |
F-15599 |
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM). |
T7350 |
Nelotanserin |
Nelotanserin is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). |
T7498 |
Eltoprazine hydrochloride |
Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). |
T7412 |
Tandospirone citrate |
Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM) |
T7519 |
RS 127445 |
RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5). |
T7521 |
Azaphen |
Azaphen is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity. |
T7694 |
6-fluoro-DL-Tryptophan |
6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis. |
TQ0084 |
lumateperone Tosylate |
Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 |
TQ0130 |
CP-809101 |
CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
TQ0311 |
GSK163090 |
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
TQ0315 |
Tandospirone |
Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM). |
T3497 |
Ocaperidona |
Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist. |
T1090 |
Perphenazine |
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
T3S0478 |
Scopolamine |
1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can increase acetylcholin |
T8128 |
Mosapride |
Mosapride is a selective 5HT4 agonist |
T8136 |
Perospirone hydrochloride |
Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
T8140 |
Tianeptine |
Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo. |
T8398 |
Lasmiditan hydrochloride |
Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM) |
T8357 |
SB-200646 |
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
TN1032 |
Geissoschizine methyl ether |
Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan |
TN1415 |
Auraptenol |
Auraptenol possesses robust antidepressant-like efficacy in mice. |
TN1465 |
Cannabigerol |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 re |
TN1812 |
Jujuboside B1 |
Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides ma |
TN2030 |
p-Hydroxyphenethyl trans-ferulate |
P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific |
TN1544 |
D-Menthol |
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur |
TN1740 |
Homoeriodictyol |
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media |
TN1755 |
Hyperforin |
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts. |
TN2116 |
Pteropodine |
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows stro |
T8413 |
Lasmiditan succinate |
Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21 nM). |
T12046 |
Mirtazapine D3 |
Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor . |
T12215 |
Nexopamil racemate |
Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo. |
T12262L |
NPS ALX Compound 4a dihydrochloride |
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM) |
T12262 |
NPS ALX Compound 4a |
NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM) |
T12489L |
Pimethixene maleate |
Pimethixene maleate is a highly potent5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(with pKis of 7.63, 10. |
T12489 |
Pimethixene |
Pimethixene is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8 |
T12480 |
Pipamperone |
Pipamperone is a high-affinity 5-HT2A receptor and D4 receptor antagonist (pKi of 8.2 and 8.0,respectively) . |
T12565 |
PRX933 hydrochloride |
PRX933 hydrochloride is an agonist of 5-HT2c receptor. |
T10075 |
2-Methyl-5-HT |
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. |
T10075L2 |
2-Methyl-5-HT hydrochloride |
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. |
T10114 |
3-Hydroxy agomelatine |
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). |
T10113 |
3-Hydroxy agomelatine D3 |
|
T10168 |
5-HT1A modulator 1 |
5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1, and dopamine D2 receptor (IC50s: 2 nM, 10 nM and 40 nM). |
T10498 |
5-HT2A antagonist 1 |
5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in the treatment of gastrointestinal disorders circulatory disorders. |
T10162 |
5-HT3 antagonist 3 |
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. It binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM). |
T10006 |
5-HT3-In-1 |
5-HT3-In-1 (compound example 8) is extracted from patent EP0748807A1 with 5-HT3 inhibition activity. |
T10169 |
5-HT4 antagonist 1 |
5-HT4 antagonist 1 is a 5-HT4 receptor antagonist (pKi: 9.6). |
T10053 |
5HT6-ligand-1 |
5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki: 1.43 nM). |
T10170 |
5-HT7 agonist 1 |
5-HT7 agonist 1 is a selective 5-HT7 receptor agonist (IC50: 222.93 nM), which can be used for the 5-HT7 receptor-related disease, such as CNS disorders. |
T10192 |
7-Desmethyl-3-hydroxyagomelatine |
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. |
T10989 |
Dehydroaripiprazole |
Dehydroaripiprazole (OPC-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroa |
T10996 |
Deramciclane |
Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C receptors, but no d |
T11075 |
Donitriptan |
Donitriptan is an effective agonist for the 5-HT1B/1D receptor, with pKis of 9.4 and 9.3, respectively. |
T10075L |
2-Methyl-5-HT maleate |
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like effects[1]. |
T8445 |
PU-02 |
PU-02 is a potent and selective antagonist of 5-HT3 receptor. |
T8438 |
4i |
4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system. |
T14190 |
Alniditan |
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. |
T14526 |
Bemesetron |
Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50: nM). It has Neuroprotective effect[2]. |
T12631 |
(R)-Mirtazapine D3 |
(R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor. |
T12632 |
(R)-Mirtazapine |
(R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a antagonist of 5-HT3 rece |
T12638 |
(R)-Praziquantel D11 |
(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel is the active enantiomer of Praziquantel, is a partial the human 5-HT2B receptor agonist |
T12716 |
RG-12915 |
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM). |
T10267 |
Agomelatine (L(+)-Tartaric acid) |
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also |
T10294 |
AM9405 |
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. It inhibits twitch contraction of the ileum and the colon (IC50s: 45.71 and 0. |
T10344 |
AP521 |
AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM). |
T10371 |
Arotinolol |
Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP |
T10380 |
AS19 |
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, |
T14782 |
Brilaroxazine |
Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity at 5-HT2B (Ki: 0.19 |
T14853 |
Cabergoline |
Cabergoline is an ergot derived-dopamine D2-like receptor agonist (Ki: 0.7, 1.5, and 1.2 for D2, D3, and 5-HT2B receptors). |
T14968 |
Cinanserin hydrochloride |
Cinanserin hydrochloride is a selective and highly affinity 5-HT2 receptor antagonist (Ki: 41 nM). It has a much higher binding affinity for the 5-HT2 than for the 5-HT1 (Ki: 3500 |
T10837L |
Clocapramine |
Clocapramine is a D2 and 5-HT2A receptors antagonist. |
T15026 |
Cyamemazine |
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 |
T15034 |
Roluperidone |
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki: 7.53 nM and 8.19 nM for 5-HT2A and sigma-2 ). |
T15100 |
Desmethyl cariprazine |
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) recepto |
T15117 |
Didesmethyl cariprazine |
Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl cariprazine is a meta |
T15270 |
Fananserin |
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki: |
T15414 |
GR 113808 |
GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8) |
T12806 |
(S)-Mirtazapine D3 |
(S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2. |
T12841 |
SB-224289 hydrochloride |
SB-224289 hydrochloride is a selective antagonist of 5-HT1B receptor, with anxiolytic effect. |
T12859L |
SB 243213 dihydrochloride |
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C recepto |
T12859 |
SB 243213 hydrochloride |
SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has improved anxiolyti |
T12842 |
SB-269970 |
SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3). |
T12843 |
SB-399885 hydrochloride |
SB-399885 hydrochloride is an antagonist of 5-HT6 receptor. |
T12855 |
SB 258719 |
SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5). |
T12988 |
5-HT3 antagonist 2 |
5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor. |
T13007 |
ST1936 oxalate |
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). |
T13021 |
Sulamserod |
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities. |
T13110 |
Tedatioxetine hydrobromide |
Tedatioxetine hydrobromide is an inhibitor of triple reuptake and antagonist of 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor. |
T11183 |
EMDT oxalate |
EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects. |
T11216 |
Eplivanserin mixture |
Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, |
T11217 |
Eplivanserin |
Eplivanserin was a potent selective oral 5-HT2 receptor antagonist, with a cortical membrane IC50 of 5.8 nM and a Kd of 1.14 nM in rats. |
T11293 |
FK1052 hydrochloride |
FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist. |
T11302 |
Flumexadol |
Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexad |
T11326 |
Frovatriptan succinate hydrate |
Frovatriptan succinate hydrate is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatr |
T10495 |
Befiradol hydrochloride |
Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor. |
T10612 |
Brexpiprazole S-oxide |
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM). |
T10611 |
Brexpiprazole S-oxide D8 |
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist |
T13339 |
Wf-516 |
Wf-516 is an 5-HT reuptake inhibitor(Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity. |
T10824 |
cis-Urocanic acid |
cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor. |
T15552 |
Iferanserin |
Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential for internal hemorrho |
T15760 |
Lintopride |
Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties. |
T16421 |
p-MPPI hydrochloride |
p-MPPI hydrochloride can cross the blood-brain barrier and has clear antidepressant and anxiolytic-like effects. p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist. It |
T8475 |
3-AQC |
3-AQC is a competitive antagonist of 5-HT3. |
T13974 |
ZL0580 |
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. |
T19381 |
Isobutyryl-L-carnitine |
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. |
T11727 |
JPH203 dihydrochloride |
JPH203 dihydrochloride is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research. |
T16283 |
Neocarzinostatin |
Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to |
T22236 |
Alprenolol hydrochloride |
Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. |
T16399 |
Opiranserin |
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist |
T16401 |
Org-12962 |
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high |
T16433 |
Pancopride |
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor. |
T16481 |
PF-04995274 |
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated wit |
T16556 |
PNU-142633 |
PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B r |
T16683 |
Pumosetrag Hydrochloride |
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
T16711 |
Flesinoxan |
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM). |
T11839 |
Lesopitron dihydrochloride |
Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist. |
T16759 |
Ritanserin |
Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM). |
T16779 |
Rodatristat ethyl |
Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hydroxylase 1 Inhibit |
T12632L |
(S)-Mirtazapine |
(S)-Mirtazapine is an S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. |
T11948 |
Masupirdine free base |
Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupird |
T11949 |
Masupirdine mesylate |
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupirdin |
T16856 |
SB228357 |
SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively). |
T17033 |
Temanogrel |
Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). |
T17095 |
TIK-301 |
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK |
T17253 |
WAY 163909 |
WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM). |
T17275 |
YM348 |
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM). |
T17285 |
Zatosetron maleate |
Zatosetron maleate is an effective and selective antagonist of the 5HT3 receptor. |
T22294 |
Cinitapride Hydrogen Tartrate |
Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors |
T22296 |
Cisapride hydrate |
Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic. |
T22340 |
Granisetron |
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy. |
T22393 |
Palonosetron |
Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). |
T22425 |
Sevoflurane |
Sevoflurane, a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics. |
T22448 |
Tropisetron |
Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. |
T8593 |
RU 24969 |
RU 24969 is a selective agonist of 5-HT1A and 5-HT1B receptors. |
T2S0118 |
Daurinoline |
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function |
T2S1397 |
L-Stepholidine |
L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti-dyskinesia effects |
T5S1389 |
Escin IB |
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central |
TN2533 |
1-Hydroxy-2,3,4,7-tetramethoxyxanthone |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 |
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in |
TN3235 |
7-Hydroxycadalene |
7-Hydroxycadalene shows cytotoxicity activity against HCT-15 cell line with IC50 18.89 ± 1.2 uM. |
TN3393 |
alpha-Yohimbine |
Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect. |
TN4092 |
Galanolactone |
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values rangi |
TMA1122 |
Moschamine |
Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP formation via binding |
TN4713 |
Onitisin |
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum. |
TN5166 |
trans-Methylisoeugenol |
(E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) ca |
T12899L |
SEP-363856 hydrochloride |
SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the |
T8666 |
Naratriptan |
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches. |
T8702 |
SKF-83566 |
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
T21629 |
Loxapine |
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