首页Autophagy5-HT Receptor
5-HT Receptor
T0025 Haloperidol Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromaz
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T0031L2 Ziprasidone Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme
T0039 Dapoxetine Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabo
T0081 Lafutidine Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.
T0088 Urapidil hydrochloride Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
T0113 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminot
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though
T0165 Urapidil Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist.
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect
T0174 Cyproheptadine hydrochloride Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
T0203 Sumatriptan succinate Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
T0204 Protriptyline hydrochloride Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride blocks the re-
T0205 Brompheniramine hydrogen maleate Brompheniramine maleate is an antagonist against histamine H1 receptors.
T0216 Eletriptan HBr Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.
T0217 Levodropropizine Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
T0225 Pizotifen Malate Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane.
T0236 Azatadine Maleate Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T0255 Clomipramine hydrochloride Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastr
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0318 Ataractan Azacyclonol is a drug used to diminish hallucinations in psychotic individuals.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0338 Minaprine dihydrochloride Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T0351 Risperidal Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0370 Pheniramine maleate Pheniramine Maleate,an alkylamine derivative with antihistaminic and vasodilatory properties,binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production
T0428 Alverine citrate Alverine Citrate is utilized in functional gastrointestinal disorders.
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0450 Fluoxetine Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres
T0450L Fluoxetine hydrochloride Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres
T0472 Venlafaxine hydrochloride Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSI
T0482 Sertraline hydrochloride Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression.
T0525 Flopropione Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace a
T0663 2-Bromo-6-methoxynaphthalene 2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T0680 Lamotrigine Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T0723 Cloperastine hydrochloride Cloperastine hydrochloride is a type of flavonoid.
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed be
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may ca
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmaco
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi
T0811 Amisulpride Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia
T0869 Atomoxetine hydrochloride Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cogni
T0965 Histamine Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, a
T0991 Desipramine hydrochloride Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochl
T1042 Granisetron hydrochloride Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its acti
T1066 Ketanserin Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities.
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T1077 Fluvoxamine maleate Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
T1081 Nafronyl oxalate Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It ma
T1092 Zolmitriptan Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerv
T1156 Palonosetron hydrochloride Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
T1170 Olopatadine hydrochloride Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
T1173 Tropisetron hydrochloride Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinausean
T1180 Blonanserin Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side e
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative
T1279 Vilazodone Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits th
T1291 Cisapride Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres
T1354 N-Acetyl-5-hydroxytryptamine N-Acetylserotonin (NAS), also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is co
T1384 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due t
T1412 Loxapine succinate salt Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T1442 Pizotifen Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating pr
T1445 Agomelatine Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an
T1471 Duloxetine hydrochloride Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLY
T1478 Ondansetron hydrochloride Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, inc
T1483 Citalopram HBr Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central
T1509 Cyclobenzaprine hydrochloride Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms.
T1512 Rizatriptan benzoate Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
T1528 Azasetron hydrochloride Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is
T1551 Tegaserod maleate Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United Sta
T1566 Aripiprazole Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS,
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1580 Desvenlafaxine Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an ant
T1619 Trazodone hydrochloride Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and o
T1636 Paroxetine hydrochloride Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- an
T1735 Lurasidone hydrochloride Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, seroton
T1769 Pardoprunox Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early
T1774 SB 742457 SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease.
T1951 Asenapine Maleate Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bi
T2076 Pimavanserin Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic
T2092 Amitifadine hydrochloride Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T2132 Buspirone hydrochloride Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T2190 Methiothepin mesylate Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic.
T2209 Serotonin hydrochloride Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS,and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
T2278 Piboserod Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
T2289 RU 24969 hemisuccinate RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors.
T2306 Brexpiprazole Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
T2317 Almotriptan Malate Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.
T2344 LY344864 LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
T2395 Vortioxetine Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations durin
T2395L Vortioxetine HBr Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
T2402 Tianeptine sodium Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.
T2428 TG6-10-1 TG6-10-1 is an EP2 antagonist.
T2459 BRL54443 BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively).
T2525 Alosetron hydrochloride Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in t
T2542 Prucalopride Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.
T2565 Hesperetin Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
T2589 Dalasetron Mesylate Hydrate Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiot
T2599 Pirenperone Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.
T2631 WAY-100635 Maleate WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
T2688 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
T2714 Rotundine Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
T2874 Tetrahydroberberine THB Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
T3046 BMY 7378 dihydrochloride BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
T3085 Piperacetazine Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
T3179 Eptapirone F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.
T3269 Metadoxine Metadoxine is a neurotransmitter stimulant.
T3275 Nefazodone hydrochloride Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
T3341 Elemicin Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human.
T3369 Nuciferine Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
T3431 Pardoprunox hydrochloride Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist a
T3453 WAY-100635 maleate salt WAY-100635 maleate is a effective and elective 5-hydroxytryptamine1A antagonist ( IC50=0.95 ± 0.12 nM).
T3526 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, a
T3648 YL0919 YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor.
T3704 Lasmiditan Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed
T4008 Metergoline Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
T6188 Desvenlafaxine succinate hydrate Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
T6232 Vilazodone HCl Vilazodone HCl,a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
T6241 Quetiapine Fumarate Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T6423 BRL-15572 dihydrochloride BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
T6426 Buclizine HCl Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to an
T6461 Dapoxetine HCl Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.
T6488 Epinastine HCl Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
T6493 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
T6562 Latrepirdine Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
T6597 Mosapride Citrate Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist.
T6600 Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
T6602 Naratriptan hydrochloride Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Nar
T6615 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
T6616 Ondansetron HCl Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
T6655 SB269970 HCl SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
T6728 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
T6814 Cyproheptadine HCl Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
T6946 Pimavanserin tartrate Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson’s disease.
T6958 Prucalopride Succinate Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
T6959 PRX-08066 Maleic acid PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.
T6973 RS127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
T4305 8-OH-Dpat 8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
T4266 LY 334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
T4297 Flibanserin Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevat
T4118 SB 271046 hydrochloride SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62,
T2226 Pergolide mesylate salt PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEAR
T4568 Dolasetron Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
T4562 Ramosetron Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st gene
T4577 Cariprazine Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A recepto
T4560 Alprenolol Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.
T4576 Perospirone Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
T4978 Sarpogrelate hydrochloride Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is
T5179 AVN492 AVN-492 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM).
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid recepto
T5336 Zacopride hydrochloride Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
T5387 LP-211 LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
T5380 Ansofaxine hydrochloride Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
T5389 Volinanserin Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1
T5271 5-Methoxytryptamine 5-Methoxytryptamine, nonselective serotonin receptor agonist that lacks affinity for the 5-HT3 receptor.
T5858 Sertindole Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, re
T7103 idalopirdine Idalopirdine, a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.
T7135 Phenylbiguanide Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
T7277 SB 242084 dihydrochloride hydrate SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.
T7281 F-15599 F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
T7350 Nelotanserin Nelotanserin is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM).
T7498 Eltoprazine hydrochloride Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
T7412 Tandospirone citrate Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)
T7519 RS 127445 RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).
T7521 Azaphen Azaphen is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
T7694 6-fluoro-DL-Tryptophan 6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.
TQ0084 lumateperone Tosylate Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2
TQ0130 CP-809101 CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
TQ0311 GSK163090 GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).
TQ0315 Tandospirone Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM).
T3497 Ocaperidona Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T3S0478 Scopolamine 1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can increase acetylcholin
T8128 Mosapride Mosapride is a selective 5HT4 agonist
T8136 Perospirone hydrochloride Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia.  It also displays affinity towards 5HT1A receptors as a partial agonist.
T8140 Tianeptine Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo.
T8398 Lasmiditan hydrochloride Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM) 
T8357 SB-200646 SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor 
TN1032 Geissoschizine methyl ether Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan
TN1415 Auraptenol Auraptenol possesses robust antidepressant-like efficacy in mice.
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 re
TN1812 Jujuboside B1 Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides ma
TN2030 p-Hydroxyphenethyl trans-ferulate P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific
TN1544 D-Menthol Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media
TN1755 Hyperforin Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
TN2116 Pteropodine Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows stro
T8413 Lasmiditan succinate Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21 nM).
T12046 Mirtazapine D3 Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .
T12215 Nexopamil racemate Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo.
T12262L NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12262 NPS ALX Compound 4a NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12489L Pimethixene maleate Pimethixene maleate is a highly potent5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(with pKis of 7.63, 10.
T12489 Pimethixene Pimethixene is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8
T12480 Pipamperone Pipamperone is a high-affinity 5-HT2A receptor and D4 receptor antagonist (pKi of 8.2 and 8.0,respectively) .
T12565 PRX933 hydrochloride PRX933 hydrochloride is an agonist of 5-HT2c receptor.
T10075 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10075L2 2-Methyl-5-HT hydrochloride 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10114 3-Hydroxy agomelatine 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
T10113 3-Hydroxy agomelatine D3
T10168 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1, and dopamine D2 receptor (IC50s: 2 nM, 10 nM and 40 nM).
T10498 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in the treatment of gastrointestinal disorders circulatory disorders.
T10162 5-HT3 antagonist 3 5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. It binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM).
T10006 5-HT3-In-1 5-HT3-In-1 (compound example 8) is extracted from patent EP0748807A1 with 5-HT3 inhibition activity.
T10169 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist (pKi: 9.6).
T10053 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki: 1.43 nM).
T10170 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist (IC50: 222.93 nM), which can be used for the 5-HT7 receptor-related disease, such as CNS disorders.
T10192 7-Desmethyl-3-hydroxyagomelatine 7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T10989 Dehydroaripiprazole Dehydroaripiprazole (OPC-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroa
T10996 Deramciclane Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C receptors, but no d
T11075 Donitriptan Donitriptan is an effective agonist for the 5-HT1B/1D receptor, with pKis of 9.4 and 9.3, respectively.
T10075L 2-Methyl-5-HT maleate 2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like effects[1].
T8445 PU-02 PU-02 is a potent and selective antagonist of 5-HT3 receptor.
T8438 4i 4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system.
T14190 Alniditan Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively.
T14526 Bemesetron Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50: nM). It has Neuroprotective effect[2].
T12631 (R)-Mirtazapine D3 (R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor.
T12632 (R)-Mirtazapine (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a antagonist of 5-HT3 rece
T12638 (R)-Praziquantel D11 (R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel is the active enantiomer of Praziquantel, is a partial the human 5-HT2B receptor agonist
T12716 RG-12915 RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
T10267 Agomelatine (L(+)-Tartaric acid) Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also
T10294 AM9405 AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. It inhibits twitch contraction of the ileum and the colon (IC50s: 45.71 and 0.
T10344 AP521 AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
T10371 Arotinolol Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP
T10380 AS19 AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM,
T14782 Brilaroxazine Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity at 5-HT2B (Ki: 0.19
T14853 Cabergoline Cabergoline is an ergot derived-dopamine D2-like receptor agonist (Ki: 0.7, 1.5, and 1.2 for D2, D3, and 5-HT2B receptors).
T14968 Cinanserin hydrochloride Cinanserin hydrochloride is a selective and highly affinity 5-HT2 receptor antagonist (Ki: 41 nM). It has a much higher binding affinity for the 5-HT2 than for the 5-HT1 (Ki: 3500
T10837L Clocapramine Clocapramine is a D2 and 5-HT2A receptors antagonist.
T15026 Cyamemazine Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75
T15034 Roluperidone Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki: 7.53 nM and 8.19 nM for 5-HT2A and sigma-2 ).
T15100 Desmethyl cariprazine Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) recepto
T15117 Didesmethyl cariprazine Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl cariprazine is a meta
T15270 Fananserin Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki:
T15414 GR 113808 GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8)
T12806 (S)-Mirtazapine D3 (S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2.
T12841 SB-224289 hydrochloride SB-224289 hydrochloride is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.
T12859L SB 243213 dihydrochloride SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C recepto
T12859 SB 243213 hydrochloride SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has improved anxiolyti
T12842 SB-269970 SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3).
T12843 SB-399885 hydrochloride SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
T12855 SB 258719 SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).
T12988 5-HT3 antagonist 2 5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor.
T13007 ST1936 oxalate ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).
T13021 Sulamserod Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
T13110 Tedatioxetine hydrobromide Tedatioxetine hydrobromide is an inhibitor of triple reuptake and antagonist of 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor.
T11183 EMDT oxalate EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects. 
T11216 Eplivanserin mixture Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, 
T11217 Eplivanserin Eplivanserin was a potent selective oral 5-HT2 receptor antagonist, with a cortical membrane IC50 of 5.8 nM and a Kd of 1.14 nM in rats.
T11293 FK1052 hydrochloride FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
T11302 Flumexadol Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexad
T11326 Frovatriptan succinate hydrate  Frovatriptan succinate hydrate is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatr
T10495 Befiradol hydrochloride Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor.
T10612 Brexpiprazole S-oxide Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).
T10611 Brexpiprazole S-oxide D8 Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist
T13339 Wf-516 Wf-516 is an 5-HT reuptake inhibitor(Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity.
T10824 cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
T15552 Iferanserin Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential for internal hemorrho
T15760 Lintopride Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.
T16421 p-MPPI hydrochloride p-MPPI hydrochloride can cross the blood-brain barrier and has clear antidepressant and anxiolytic-like effects. p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist. It
T8475 3-AQC 3-AQC is a competitive antagonist of 5-HT3.
T13974 ZL0580 ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
T19381 Isobutyryl-L-carnitine Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T11727 JPH203 dihydrochloride JPH203 dihydrochloride is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research.
T16283 Neocarzinostatin Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to
T22236 Alprenolol hydrochloride Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.
T16399 Opiranserin Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist
T16401 Org-12962 Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high
T16433 Pancopride Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
T16481 PF-04995274 PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated wit
T16556 PNU-142633 PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B r
T16683 Pumosetrag Hydrochloride Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
T16711 Flesinoxan Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
T11839 Lesopitron dihydrochloride Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist.
T16759 Ritanserin Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
T16779 Rodatristat ethyl Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hydroxylase 1 Inhibit
T12632L (S)-Mirtazapine (S)-Mirtazapine is an S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist.
T11948 Masupirdine free base Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupird
T11949 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupirdin
T16856 SB228357 SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively).
T17033 Temanogrel Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM).
T17095 TIK-301 TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK
T17253 WAY 163909 WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).
T17275 YM348 YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
T17285 Zatosetron maleate Zatosetron maleate is an effective and selective antagonist of the 5HT3 receptor.
T22294 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors
T22296 Cisapride hydrate Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
T22340 Granisetron Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
T22393 Palonosetron Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
T22425 Sevoflurane Sevoflurane, a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics.
T22448 Tropisetron Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
T8593 RU 24969 RU 24969 is a selective agonist of 5-HT1A and 5-HT1B receptors.
T2S0118 Daurinoline Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function
T2S1397 L-Stepholidine L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti-dyskinesia effects
T5S1389 Escin IB Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central
TN2533 1-Hydroxy-2,3,4,7-tetramethoxyxanthone 1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in
TN3235 7-Hydroxycadalene 7-Hydroxycadalene shows cytotoxicity activity against HCT-15 cell line with IC50 18.89 ± 1.2 uM.
TN3393 alpha-Yohimbine Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
TN4092 Galanolactone Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values rangi
TMA1122 Moschamine Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP formation via binding
TN4713 Onitisin Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
TN5166 trans-Methylisoeugenol (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) ca
T12899L SEP-363856 hydrochloride SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the
T8666 Naratriptan Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.
T8702 SKF-83566 SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM
T21629 Loxapine
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