| T0025 | Haloperidol | Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromaz |
| T0031 | Ziprasidone hydrochloride monohydrate | Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity。 |
| T0031L | Ziprasidone hydrochloride | Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
| T0031L2 | Ziprasidone | Ziprasidone is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
| T0039 | Dapoxetine | Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. |
| T0074 | Chlorprothixene | Chlorprothixene is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized. |
| T0074L | Chlorprothixene hydrochloride | Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti |
| T0076 | Paliperidone | Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabo |
| T0081 | Lafutidine | Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion. |
| T0088 | Urapidil hydrochloride | Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. |
| T0113 | Mebhydrolin napadisylate | Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis. |
| T0137 | Mirtazapine | Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminot |
| T0162 | Quetiapin | Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though |
| T0165 | Urapidil | Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. |
| T0172 | Maprotiline hydrochloride | Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect |
| T0174 | Cyproheptadine hydrochloride | Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2. |
| T0185 | Escitalopram | Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics an |
| T0203 | Sumatriptan succinate | Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. |
| T0204 | Protriptyline hydrochloride | Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride blocks the re- |
| T0205 | Brompheniramine hydrogen maleate | Brompheniramine maleate is an antagonist against histamine H1 receptors. |
| T0216 | Eletriptan HBr | Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor. |
| T0217 | Levodropropizine | Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug. |
| T0225 | Pizotifen Malate | Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane. |
| T0236 | Azatadine Maleate | Azatadine dimaleate is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）. |
| T0255 | Clomipramine hydrochloride | Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastr |
| T0302 | Triflupromazine hydrochloride | Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists. |
| T0318 | Ataractan | Azacyclonol is a drug used to diminish hallucinations in psychotic individuals. |
| T0333 | Aniracetam | Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR. |
| T0338 | Minaprine | Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states. |
| T0351 | Risperidal | Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
| T0365 | Thioridazine hydrochloride | Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. |
| T0370 | Pheniramine maleate | Pheniramine Maleate, an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production o |
| T0428 | Alverine citrate | Alverine Citrate is utilized in functional gastrointestinal disorders. |
| T0445 | Promethazine | Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) . |
| T0450 | Fluoxetine | Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres |
| T0450L | Fluoxetine hydrochloride | Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepres |
| T0472 | Venlafaxine hydrochloride | Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSI |
| T0482 | Sertraline hydrochloride | Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
| T0525 | Flopropione | Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
| T0647 | Tryptamine | Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace a |
| T0663 | 2-Bromo-6-methoxynaphthalene | 2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction. |
| T0678 | Amitriptyline hydrochloride | Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
| T0680 | Lamotrigine | Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| T0716 | Molindone hydrochloride | Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain. |
| T0723 | Cloperastine hydrochloride | Cloperastine hydrochloride is a type of flavonoid. |
| T0735 | Pindolol | Pindolol is a moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing |
| T0766 | Promazine hydrochloride | Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed be |
| T0783 | Mianserin hydrochloride | Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may ca |
| T0785 | Dexchlorpheniramine Maleate | Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmaco |
| T0802 | Procaine hydrochloride | Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi |
| T0811 | Amisulpride | Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia |
| T0869 | Atomoxetine hydrochloride | Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cogn |
| T0965 | Histamine | Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, a |
| T0991 | Desipramine hydrochloride | Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochl |
| T10006 | 5-HT3-In-1 | 5-HT3-In-1 (compound example 8) is extracted from patent EP0748807A1 with 5-HT3 inhibition activity. |
| T10053 | 5HT6-ligand-1 | 5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki: 1.43 nM). |
| T10075 | 2-Methyl-5-HT | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. |
| T10075L | 2-Methyl-5-HT maleate | 2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like effects[1]. |
| T10075L2 | 2-Methyl-5-HT hydrochloride | 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. |
| T10113 | 3-Hydroxy agomelatine D3 | |
| T10114 | 3-Hydroxy agomelatine | 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). |
| T10162 | 5-HT3 antagonist 3 | 5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. It binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM). |
| T10168 | 5-HT1A modulator 1 | 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1, and dopamine D2 receptor (IC50s: 2 nM, 10 nM and 40 nM). |
| T10169 | 5-HT4 antagonist 1 | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist (pKi: 9.6). |
| T10170 | 5-HT7 agonist 1 | 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist (IC50: 222.93 nM), which can be used for the 5-HT7 receptor-related disease, such as CNS disorders. |
| T10192 | 7-Desmethyl-3-hydroxyagomelatine | 7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. |
| T10267 | Agomelatine (L(+)-Tartaric acid) | Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also |
| T10294 | AM9405 | AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. It inhibits twitch contraction of the ileum and the colon (IC50s: 45.71 and 0. |
| T10344 | AP521 | AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM). |
| T10371 | Arotinolol | Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP |
| T10380 | AS19 | AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, |
| T1042 | Granisetron hydrochloride | Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients. |
| T1045 | Trimipramine maleate | Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its acti |
| T10495 | Befiradol hydrochloride | Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor. |
| T10498 | 5-HT2A antagonist 1 | 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in the treatment of gastrointestinal disorders circulatory disorders. |
| T10611 | Brexpiprazole S-oxide D8 | Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist |
| T10612 | Brexpiprazole S-oxide | Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM). |
| T1066 | Ketanserin | Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. |
| T1069 | Metoclopramide hydrochloride | Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic. |
| T1077 | Fluvoxamine maleate | Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders. |
| T1081 | Nafronyl oxalate | Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It ma |
| T10824 | cis-Urocanic acid | cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor. |
| T10837L | Clocapramine | Clocapramine is a D2 and 5-HT2A receptors antagonist. |
| T1090 | Perphenazine | Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
| T1092 | Zolmitriptan | Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerv |
| T10989 | Dehydroaripiprazole | Dehydroaripiprazole (OPC-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroa |
| T10996 | Deramciclane | Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C receptors, but no d |
| T11075 | Donitriptan | Donitriptan is an effective agonist for the 5-HT1B/1D receptor, with pKis of 9.4 and 9.3, respectively. |
| T11183 | EMDT oxalate | EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects. |
| T11216 | Eplivanserin mixture | Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, |
| T11217 | Eplivanserin | Eplivanserin was a potent selective oral 5-HT2 receptor antagonist, with a cortical membrane IC50 of 5.8 nM and a Kd of 1.14 nM in rats. |
| T11293 | FK1052 hydrochloride | FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist. |
| T11302 | Flumexadol | Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexad |
| T11326 | Frovatriptan succinate hydrate | Frovatriptan succinate hydrate is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatrip |
| T1156 | Palonosetron hydrochloride | Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| T1170 | Olopatadine hydrochloride | Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS. |
| T11727 | JPH203 dihydrochloride | JPH203 dihydrochloride is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research. |
| T1173 | Tropisetron hydrochloride | Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinausean |
| T1180 | Blonanserin | Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side e |
| T11839 | Lesopitron dihydrochloride | Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist. |
| T11948 | Masupirdine free base | Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupird |
| T11949 | Masupirdine mesylate | Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupirdin |
| T12046 | Mirtazapine D3 | Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor . |
| T12215 | Nexopamil racemate | Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo. |
| T12262 | NPS ALX Compound 4a | NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM) |
| T12262L | NPS ALX Compound 4a dihydrochloride | NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM) |
| T12480 | Pipamperone | Pipamperone is a high-affinity 5-HT2A receptor and D4 receptor antagonist (pKi of 8.2 and 8.0,respectively) . |
| T12489 | Pimethixene | Pimethixene is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8 |
| T12489L | Pimethixene maleate | Pimethixene maleate is a highly potent5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(with pKis of 7.63, 10. |
| T12565 | PRX933 hydrochloride | PRX933 hydrochloride is an agonist of 5-HT2c receptor. |
| T12631 | (R)-Mirtazapine D3 | (R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor. |
| T12632 | (R)-Mirtazapine | (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a antagonist of 5-HT3 rece |
| T12632L | (S)-Mirtazapine | (S)-Mirtazapine is an S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. |
| T12638 | (R)-Praziquantel D11 | (R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel is the active enantiomer of Praziquantel, is a partial the human 5-HT2B receptor agonist |
| T1266 | Terfenadine | Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative |
| T12716 | RG-12915 | RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM). |
| T12773 | RS102895 hydrochloride | RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM). |
| T1279 | Vilazodone | Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits th |
| T12806 | (S)-Mirtazapine D3 | (S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2. |
| T12841 | SB-224289 hydrochloride | SB-224289 hydrochloride is a selective antagonist of 5-HT1B receptor, with anxiolytic effect. |
| T12842 | SB-269970 | SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3). |
| T12843 | SB-399885 hydrochloride | SB-399885 hydrochloride is an antagonist of 5-HT6 receptor. |
| T12855 | SB 258719 | SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5). |
| T12859 | SB 243213 hydrochloride | SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has improved anxiolyti |
| T12859L | SB 243213 dihydrochloride | SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C recepto |
| T12899L | SEP-363856 hydrochloride | SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the |
| T1291 | Cisapride | Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase |
| T12988 | 5-HT3 antagonist 2 | 5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor. |
| T13007 | ST1936 oxalate | ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). |
| T13021 | Sulamserod | Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities. |
| T13110 | Tedatioxetine hydrobromide | Tedatioxetine hydrobromide is an inhibitor of triple reuptake and antagonist of 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor. |
| T1317 | Cinchonidine | Cinchonidine is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine. |
| T1327 | Nortriptyline hydrochloride | Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres |
| T13339 | Wf-516 | Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity. |
| T1384 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due t |
| T13974 | ZL0580 | ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. |
| T1412 | Loxapine succinate salt | Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia. |
| T14190 | Alniditan | Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. |
| T1442 | Pizotifen | Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating pr |
| T1445 | Agomelatine | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an |
| T14526 | Bemesetron | Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50: nM). It has Neuroprotective effect[2]. |
| T1471 | Duloxetine hydrochloride | Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLY |
| T1478 | Ondansetron hydrochloride | Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, inc |
| T14782 | Brilaroxazine | Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity at 5-HT2B (Ki: 0.19 |
| T1483 | Citalopram HBr | Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central |
| T14853 | Cabergoline | Cabergoline is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits ra |
| T14968 | Cinanserin hydrochloride | Cinanserin hydrochloride is a selective and highly affinity 5-HT2 receptor antagonist (Ki: 41 nM). It has a much higher binding affinity for the 5-HT2 than for the 5-HT1 (Ki: 3500 |
| T15026 | Cyamemazine | Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 |
| T15034 | Roluperidone | Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki: 7.53 nM and 8.19 nM for 5-HT2A and sigma-2 ). |
| T1509 | Cyclobenzaprine hydrochloride | Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms. |
| T15100 | Desmethyl cariprazine | Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) recepto |
| T15117 | Didesmethyl cariprazine | Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl cariprazine is a meta |
| T1512 | Rizatriptan benzoate | Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches. |
| T15270 | Fananserin | Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki: |
| T1528 | Azasetron hydrochloride | Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic. |
| T1540 | Doxepin hydrochloride | Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is |
| T15414 | GR 113808 | GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8) |
| T1551 | Tegaserod maleate | Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United Sta |
| T15552 | Iferanserin | Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential for internal hemorrho |
| T1566 | Aripiprazole | Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, |
| T1567 | Olanzapine | Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
| T15760 | Lintopride | Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties. |
| T1580 | Desvenlafaxine | Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an ant |
| T1619 | Trazodone hydrochloride | Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and o |
| T16283 | Neocarzinostatin | Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to |
| T1636 | Paroxetine hydrochloride | Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. |
| T16399 | Opiranserin | Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist |
| T16401 | Org-12962 | Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high |
| T16421 | p-MPPI hydrochloride | p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. |
| T16433 | Pancopride | Pancopride is a new effective and selective antagonist of the 5-HT3 receptor. |
| T1644 | Dopamine hydrochloride | Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- an |
| T16481 | PF-04995274 | PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated wit |
| T16556 | PNU-142633 | PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B r |
| T16683 | Pumosetrag Hydrochloride | Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
| T16711 | Flesinoxan | Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM). |
| T16759 | Ritanserin | Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM). |
| T16779 | Rodatristat ethyl | Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hydroxylase 1 Inhibit |
| T16856 | SB228357 | SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively). |
| T17033 | Temanogrel | Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). |
| T17095 | TIK-301 | TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK |
| T17253 | WAY 163909 | WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM). |
| T17275 | YM348 | YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM). |
| T17285 | Zatosetron maleate | Zatosetron maleate is an effective and selective antagonist of the 5HT3 receptor. |
| T1735 | Lurasidone hydrochloride | Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, seroton |
| T1769 | Pardoprunox | Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early |
| T1774 | SB 742457 | SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease. |
| T19381 | Isobutyryl-L-carnitine | Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. |
| T1951 | Asenapine Maleate | Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bi |
| T2076 | Pimavanserin | Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic |
| T2092 | Amitifadine hydrochloride | Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
| T21013 | Clomipramine | Clomipramine is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It |
| T21231 | Almotriptan | Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan is a triptan drug for treatment of migraine headaches.Binding of the drug to the receptor leads to va |
| T2132 | Buspirone hydrochloride | Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). |
| T21337 | Lurasidone | Lurasidone is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM). |
| T2190 | Methiothepin mesylate | Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic. |
| T2209 | Serotonin hydrochloride | Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
| T22236 | Alprenolol hydrochloride | Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. |
| T2226 | Pergolide mesylate salt | PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEAR |
| T22294 | Cinitapride Hydrogen Tartrate | Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors |
| T22296 | Cisapride hydrate | Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic. |
| T22340 | Granisetron | Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy. |
| T22359 | MDL 100009 | MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A. |
| T22359 | MDL 100009 | MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A. |
| T22379L | NLX-204 hydrochloride（2170405-10-2 free base） | NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19). |
| T22379L | NLX-204 hydrochloride（2170405-10-2 free base） | NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19). |
| T22393 | Palonosetron | Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). |
| T22425 | Sevoflurane | Sevoflurane, a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics. |
| T22448 | Tropisetron | Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. |
| T2278 | Piboserod | Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist. |
| T2289 | RU 24969 hemisuccinate | RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors. |
| T2306 | Brexpiprazole | Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
| T2317 | Almotriptan Malate | Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults. |
| T2344 | LY344864 | LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
| T2395 | Vortioxetine | Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations durin |
| T2395L | Vortioxetine HBr | Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM). |
| T2402 | Tianeptine sodium | Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes. |
| T2428 | TG6-10-1 | TG6-10-1 is an EP2 antagonist. |
| T2459 | BRL54443 | BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively). |
| T2525 | Alosetron hydrochloride | Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in t |
| T2542 | Prucalopride | Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. |
| T2565 | Hesperetin | Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. |
| T2589 | Dalasetron Mesylate Hydrate | Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiot |
| T2599 | Pirenperone | Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action. |
| T2631 | WAY-100635 Maleate | WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). |
| T2688 | LY310762 | LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
| T2714 | Rotundine | Rotundine is extracted from Corydalis yanhusuo W. T. Wang. |
| T2815 | Puerarin | Puerarin, also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. |
| T2874 | Tetrahydroberberine THB | Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors. |
| T2S0007 | Sodium ferulic | Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent th |
| T2S0118 | Daurinoline | Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function |
| T2S1397 | L-Stepholidine | L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti-dyskinesia effects |
| T3046 | BMY 7378 dihydrochloride | BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor. |
| T3085 | Piperacetazine | Piperacetazine, an antipsychotic prodrug, is used forschizophrenia. |
| T3086 | Mesoridazine Besylate | Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thiori |
| T3179 | Eptapirone | F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential. |
| T3183 | WAY181187 | WAY-181187 has high-affinity binding at the human 5-HT6 receptor. |
| T3269 | Metadoxine | Metadoxine is a neurotransmitter stimulant. |
| T3275 | Nefazodone hydrochloride | Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. |
| T3341 | Elemicin | Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human. |
| T3369 | Nuciferine | Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
| T3431 | Pardoprunox hydrochloride | Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist a |
| T3453 | WAY-100635 maleate salt | WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). |
| T3497 | Ocaperidona | Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist. |
| T3526 | Dasotraline hydrochloride | Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, a |
| T3648 | YL0919 | YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor. |
| T3704 | Lasmiditan | Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed |
| T3S0478 | Scopolamine | 1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can increase acetylcholine |
| T4008 | Metergoline | Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy. |
| T4118 | SB 271046 hydrochloride | SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, |
| T4266 | LY 334370 | LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM |
| T4297 | Flibanserin | Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevat |
| T4305 | 8-OH-Dpat | 8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. |
| T4375 | Methiothepin maleate | Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. |
| T4494 | CLOZAPINE N-OXIDE | Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action o |
| T4560 | Alprenolol | Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
| T4562 | Ramosetron | Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st gene |
| T4568 | Dolasetron | Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
| T4576 | Perospirone | Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
| T4577 | Cariprazine | Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A recepto |
| T4978 | Sarpogrelate hydrochloride | Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is |
| T4S1659 | Xanthotoxol | Xanthotoxol is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
| T5158 | N-Desmethylclozapine | N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid recepto |
| T5179 | AVN492 | AVN-492 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM). |
| T5271 | 5-Methoxytryptamine | 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. |
| T5336 | Zacopride hydrochloride | Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. |
| T5380 | Ansofaxine hydrochloride | Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively). |
| T5387 | LP-211 | LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor. |
| T5389 | Volinanserin | Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 |
| T5858 | Sertindole | Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, re |
| T5S1389 | Escin IB | Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central |
| T6188 | Desvenlafaxine succinate hydrate | Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI). |
| T6232 | Vilazodone HCl | Vilazodone HCl, a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder. |
| T6241 | Quetiapine Fumarate | Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
| T6423 | BRL-15572 dihydrochloride | BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. |
| T6426 | Buclizine HCl | Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to an |
| T6461 | Dapoxetine HCl | Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation. |
| T6488 | Epinastine HCl | Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
| T6493 | Escitalopram Oxalate | Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
| T6562 | Latrepirdine | Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
| T6597 | Mosapride Citrate | Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist. |
| T6600 | Naftopidil DiHCl | Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
| T6602 | Naratriptan hydrochloride | Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Nar |
| T6615 | Ondansetron | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
| T6616 | Ondansetron HCl | Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. |
| T6655 | SB269970 HCl | SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors. |
| T6656 | SB271046 | SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. |
| T6728 | VUF 10166 | VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
| T6814 | Cyproheptadine HCl | Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
| T6946 | Pimavanserin tartrate | Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease. |
| T6958 | Prucalopride Succinate | Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively. |
| T6959 | PRX-08066 Maleic acid | PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2. |
| T6973 | RS127445 | RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. |
| T6S0654 | Isocorynoxeine | 1. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant ne |
| T7103 | idalopirdine | Idalopirdine, a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease. |
| T7135 | Phenylbiguanide | Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM) |
| T7277 | SB 242084 dihydrochloride hydrate | SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor. |
| T7281 | F-15599 | F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM). |
| T7350 | Nelotanserin | Nelotanserin is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). |
| T7412 | Tandospirone citrate | Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM) |
| T7498 | Eltoprazine hydrochloride | Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). |
| T7519 | RS 127445 | RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5). |
| T7521 | Azaphen | Azaphen is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity. |
| T7694 | 6-fluoro-DL-Tryptophan | 6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis. |
| T8128 | Mosapride | Mosapride is a selective 5HT4 agonist |
| T8136 | Perospirone hydrochloride | Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
| T8140 | Tianeptine | Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo. |
| T8357 | SB-200646 | SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
| T8398 | Lasmiditan hydrochloride | Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM) |
| T8413 | Lasmiditan succinate | Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21 nM). |
| T8438 | 4i | 4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system. |
| T8441 | Lerisetron | Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity. |
| T8445 | PU-02 | PU-02 is a potent and selective antagonist of 5-HT3 receptor. |
| T8475 | 3-AQC | 3-AQC is a competitive antagonist of 5-HT3. |
| T8593 | RU 24969 | RU 24969 is a selective agonist of 5-HT1A and 5-HT1B receptors. |
| T8666 | Naratriptan | Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches. |
| T8702 | SKF-83566 | SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
| T8720 | PRX-07034 | PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 is |
| T8737 | GR 125743 | GR 125743 is a novel antagonist of 5-HT1B/1D receptor. |
| T8737 | GR 125743 | GR 125743 is a novel antagonist of 5-HT1B/1D receptor. |
| T8757 | R-Lorcaserin hydrochloride hemihydrate | R-Lorcaserin hydrochloride hemihydrate is a selective 5HT2C serotonin receptor agonist. |
| TJS0341 | 7-Amino-4-(trifluoromethyl)coumarin | 7-Amino-4-(trifluoromethyl)coumarin is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. |
| TMA1122 | Moschamine | Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP formation via binding |
| TN1032 | Geissoschizine methyl ether | Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a po |
| TN1415 | Auraptenol | Auraptenol possesses robust antidepressant-like efficacy in mice. |
| TN1465 | Cannabigerol | Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 re |
| TN1544 | D-Menthol | Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neur |
| TN1740 | Homoeriodictyol | Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media |
| TN1755 | Hyperforin | Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts. |
| TN1812 | Jujuboside B1 | Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides ma |
| TN2030 | p-Hydroxyphenethyl trans-ferulate | P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific |
| TN2116 | Pteropodine | Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows stro |
| TN2533 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone | 1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 |
| TN2534 | 1-Hydroxy-2,3,5-trimethoxyxanthone | 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in |
| TN3235 | 7-Hydroxycadalene | 7-Hydroxycadalene shows cytotoxicity activity against HCT-15 cell line with IC50 18.89 ± 1.2 uM. |
| TN3393 | alpha-Yohimbine | Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect. |
| TN4092 | Galanolactone | Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values rangi |
| TN4713 | Onitisin | Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum. |
| TN5166 | trans-Methylisoeugenol | (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) ca |
| TQ0084 | lumateperone Tosylate | Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 |
| TQ0130 | CP-809101 | CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
| TQ0311 | GSK163090 | GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
| TQ0315 | Tandospirone | Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM). |
