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搜索结果

"Taminadenant mesylate" 的搜索结果

目录号	产品详情	靶点
T69723	Taminadenant mesylate	Others
T69723	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.	Others
T16980	Taminadenant	Adenosine Receptor
T16980	Taminadenant 是一种腺苷受体拮抗剂。	Adenosine Receptor