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T2825
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Hedgehog/Smoothened
Endogenous Metabolite
Smo
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| Cyclopamine 是Hedgehog 通路的拮抗剂，细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。 |
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T35558
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| Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated oncogene 1 (Gli1) and cytosolic MMP-9, pERK1, and pERK2 proteins in a dose-dependent manner. Cyclopamine-KAAD also increases TRAIL-mediated cell death in NCH82 and NCH89 human glioblastoma cultures and upregulates expression of the death receptors DR4 and DR5 in LN229 and U251 glioma cells. |
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T23027
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Hedgehog/Smoothened
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| MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂，通过多种 Hedgehog (Hh) 测定，其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。 |
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T1810
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Hedgehog/Smoothened
Autophagy
Smo
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| Purmorphamine 是平滑受体激动剂，EC50为 1 μM。它阻止 BODIPY-cyclopamine 与 Smo 结合。它也是成骨细胞分化的诱导剂。 |
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T2299
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Hedgehog/Smoothened
Apoptosis
Smo
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| BMS-833923 是一种口服生物可利用的 Smoothened 拮抗剂，以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合，IC50为21 nM。 |
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T4592
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Autophagy
JNK
NF-κB
Others
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| Tomatidine hydrochloride 是一种甾体生物碱，可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用，可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 |
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T9532
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Others
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| MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。 |
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T40465
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Hedgehog/Smoothened
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| SAG dihydrochloride 是一种强效的 Smoothened（Smo）受体激动剂（EC 50 =3 nM；K d =59 nM）。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。 |
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T1779
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Hedgehog/Smoothened
Smo
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| Smoothened Agonist 是 Smoothened (Smo)受体激动剂 (EC50=3 nM;Kd=59 nM)。它能够激活 Hedgehog 信号通路，抵消 Cyclopamine 对 Smo 的抑制作用。 |
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T38767
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| MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in the study of cancer disease, MRT-83 (hydrochloride) demonstrates promising prospects for research purposes. |
