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"1691221-67-6" 的搜索结果

Targets Recommended: S6 Kinase

相关产品

目录号	产品详情		靶点
T70273	APTO-253 HCl		Others
T70273	APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.		Others
T10352	APTO-253	LOR-253,LT-253	Apoptosis c-Myc KLF
T10352	APTO-253 (LOR-253) 抑制 c-Myc 表达，稳定 G-四链体 DNA，并诱导急性髓细胞白血病细胞的细胞周期停滞和凋亡。它通过诱导 KLF4 肿瘤抑制因子介导抗癌活性，具有抗关节炎活性。		Apoptosis c-Myc KLF
T70706	APTO-253 isomer		Others
T70706	APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.		Others