目录号 | 产品详情 | 靶点 | |
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T20766 | Antibacterial | ||
Sulfisoxazole acetyl (Gantrisin) 是 Sulfisoxazole 的一种衍生物,是口服有效的二氢蝶酸合酶抑制剂。Sulfisoxazole acetyl 显示出抗菌作用。 | |||
T6449 | Antibacterial Antibiotic | ||
Clindamycin palmitate hydrochloride (Clindamycin palmitate HCl) 是克林霉素和棕榈酸酯的盐酸盐,是一种林可酰胺抗生素。 | |||
T21435 | Antibacterial | ||
Sulfamoxole (Sulfamoxol) 是一种广谱化疗抗菌剂,可用于小儿感染的相关研究。 | |||
T5289 | Others Endogenous Metabolite | ||
N-Acetyl-L-arginine dihydrate (N-Ac-L-arg-OH) 是内源性代谢产物的一种。 | |||
T25214 | Antibiotic | ||
CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性,可用于研究乳腺癌和小儿骨髓增生异常。 | |||
T4994 | Others | ||
Tocofersolan (TPGS) 是合成的 α-生育酚的聚乙二醇衍生物。 | |||
T8053 | Endogenous Metabolite | ||
N-Acetyl-L-arginine (Ac-Arg-OH) 是一种胍基诺化合物,被发现存在于血液渗析性肾不足儿童患者血清中的。 | |||
T40519 | |||
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research. | |||
T20858 | |||
Metanilic acid, an anti-cancer drug, is used to treat several malignancies including choriocarcinoma and pediatric acute lymphoblastic leukemia. | |||
T20673 | |||
Clofedanol, also known as chlophedianol or antitussin, is used in the treatment of pediatric pertussis. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05242 | CRLF2/TSLPR Protein, Human, Recombinant (His) | Human | HEK293 | ||
Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL. The high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of ALL and has significance in an integrated prognostic model for adult high-risk ALL. Thymic stromal lymphopoietin (TSLP) stimulates in-vitro proliferation of human fetal B-cell precursors. However, its in-vivo role during normal human B lymphopoiesis is unknown. Genetic alterations that cause overexpression of its receptor component, cytokine receptor-like factor 2 (CRLF2), lead to high-risk B-cell acute lymphoblastic leukemia implicating this signaling pathway in leukemogenesis. CRLF2 over-expression is a poor prognostic marker identifying a subset of HR T-ALL patients that could benefit from alternative therapy, potentially targeting the CRLF2 pathway. Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. Cytokine receptor-like factor 2(CRLF2) plays an important role in the development of normal B lymphocytes, which can mediate early B cell proliferation and survival.
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TMPY-00518 | SBDS Protein, Human, Recombinant (His) | Human | E. coli | ||
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
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TMPJ-00623 | BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc) | Rhesus Macaque | Human Cells | ||
TNFSF13B is also known as B-cell activating factor (BAFF), BLyS and TNLG7A, is a member of TNF ligand superfamily. TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. Identification of TNFSF13B as candidate causative genes supports conjectures on involvement of the immune system in BVVL and amyotrophic lateral sclerosis. It’s reported that APRIL, BAFF, and BAFF receptors play a major role in the pathogenesis of RA, and MSCT seems to inhibit these immunological factors.
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TMPY-00452 | SBDS Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
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TMPY-05769 | CRLF2/TSLPR Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL. The high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of ALL and has significance in an integrated prognostic model for adult high-risk ALL. Thymic stromal lymphopoietin (TSLP) stimulates in-vitro proliferation of human fetal B-cell precursors. However, its in-vivo role during normal human B lymphopoiesis is unknown. Genetic alterations that cause overexpression of its receptor component, cytokine receptor-like factor 2 (CRLF2), lead to high-risk B-cell acute lymphoblastic leukemia implicating this signaling pathway in leukemogenesis. CRLF2 over-expression is a poor prognostic marker identifying a subset of HR T-ALL patients that could benefit from alternative therapy, potentially targeting the CRLF2 pathway. Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. Cytokine receptor-like factor 2(CRLF2) plays an important role in the development of normal B lymphocytes, which can mediate early B cell proliferation and survival.
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