目录号 | 产品详情 | 靶点 | |
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T0160 | PDE | ||
Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM),是咪唑喹唑啉衍生物。它能够抑制血小板生成,以及抗血栓形成作用,可用作血小板聚集抑制剂。 | |||
T4570 | Others DNA Alkylator/Crosslinker | ||
Pipobroman (Vercyte) 是一种烷基化剂,是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性,可用于癌症研究。 | |||
T1995 | Apoptosis FLT c-RET JAK | ||
Fedratinib (TG-101348) 是选择性,ATP 竞争性和具有口服活性的 JAK2抑制剂,对于 JAK2和JAK2V617F 激酶的IC50均为 3 nM。它是对JAK2的选择性分别比 JAK1 和 JAK3 高 35 倍和 334 倍。它可诱导癌细胞凋亡,并可用于骨髓增生性疾病的研究。 | |||
T9251 | Apoptosis JAK | ||
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) 是一种选择性的,ATP 竞争性和具有口服活性的JAK2抑制剂,对于JAK2和JAK2V617F 激酶的IC50均为 3 nM。它可诱导癌细胞凋亡,可研究骨髓增生性疾病。 | |||
T10009 | JAK | ||
JAK3-IN-7 是一种有效的选择性 JAK3 抑制剂(IC50<0.01 μM),可用于治疗器官移植中的排斥反应、器官移植后的移植物抗宿主反应、自身免疫性疾病、过敏性疾病和慢性骨髓增生性疾病。 | |||
T71313 | |||
BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning into therapeutic strategies for treatment of chronic myelogenous leukemia (CML). | |||
T9634 | |||
Bomedemstat (IMG-7289) 是一种有效的,具有口服活性的且不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,具有表观遗传活性。Bomedemstat 具有抗癌活性,可用于急性髓性白血病 (AML) 和骨髓纤维化 (MF) 的研究。 | |||
T76853 | |||
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) 为单聚乙二醇化IFN-α类化合物,主要应用于骨髓增性肿瘤研究领域。 | |||
T64227 | |||
JAK2 JH2 binder-1 是一种有效的、选择性的 JAK2 JH2 结合剂 (Ki: 37.1 nM)。JAK2 JH2 binder-1 具有用于研究各种骨髓增生性肿瘤的潜力。 | |||
T73567 | |||
ZT55 是一种口服有效并具有高选择性的JAK2抑制剂,其IC50值为 0.031 μM。ZT55 能抑制表达JAK2V617F 的 HEL 细胞系的增殖,并诱导细胞凋亡和周期停滞。ZT-55 还可有效抑制小鼠模型体内 HEL 异种移植肿瘤的生长。ZT-55 可用于骨髓增生性肿瘤、多血症以及原发性血小板增多症的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00235 | TPO Protein, Human, Recombinant (His) | Human | Human Cells | ||
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
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TMPY-00939 | Thrombopoietin Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.
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TMPK-00877 | C-MPL Protein, Human, Recombinant (aa 26-491, His) | Human | HEK293 | ||
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
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TMPK-00940 | C-MPL Protein, Mouse, Recombinant (aa 26-482, His) | Mouse | HEK293 | ||
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
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TMPK-00494 | C-MPL Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 | ||
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
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TMPY-03455 | FGFR1OP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
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TMPY-01609 | Thrombopoietin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 | ||
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.
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TMPJ-00541 | CD177 Protein, Human, Recombinant (His) | Human | Human Cells | ||
CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors,and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia. It is reported that CD177 functions as a novel heterophilic binding partner that engages PECAM-1 in membrane-proximal IgD6.
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TMPY-04201 | Thrombopoietin Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.
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