T1069
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Dopamine Receptor
5-HT Receptor
AChR
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Metoclopramide hydrochloride (Metoclopramide HCl) 是可口服的5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,用于恶心呕吐、胃食管反流和胃轻瘫的研究。 |
T4616
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Dopamine Receptor
5-HT Receptor
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Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。 |
T8385
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Dopamine Receptor
5-HT Receptor
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Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。 |
T38754
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Dopamine Receptor
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Trazpiroben (TAK-906) 是一种选择性多巴胺 D2/D3 受体拮抗剂,用于研究胃痉挛。 |
TP2403
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Recanaclotide can be used to treat Gastroparesis, Functional Dyspepsia, and Other Gastrointestinal Disorders. |
T71632
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TZP-102 is a potent, oral, ghrelin receptor agonist that has been shown to improve diabetic gastroparesis symptoms. |
T35046
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Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome. |
T62973
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DS-3801b 是一种强效的、非大环内酯类 GPR38 激动剂。DS-3801b 具有潜力成为研究功能性胃肠道疾病(如胃痉挛、慢性便秘)的新型胃肠道促动剂。 |
T39236
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Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for its potential applications in research related to cachexia, gastroparesis, and gastric/intestinal dysmobility disorders [4] [5]. |
T75262
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Relamorelin (RM-131) TFA,一种生长素类似物,是一种选择性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂,对GHS-1a 受体的Ki 值为 0.42 nM。Relamorelin TFA 是一种五肽,具有中枢渗透性。Relamorelin TFA 增加生长激素水平,加速胃排空,具有用于恶病质、胃轻瘫和胃/肠运动障碍研究的潜力。 |