目录号 | 产品详情 | 靶点 | |
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T2583 | Proteasome Antibacterial Antibiotic | ||
Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂,IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM,可用作抗菌辅助剂。 | |||
T6411 | Antibacterial Antibiotic | ||
Biapenem (CLI 86815) 是不经肠道的广谱碳青霉烯抗生素。 | |||
T2583L | |||
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. | |||
T71317 | |||
WS1358A1 disodium is a potent inhibitor of renal dehydropeptidase. | |||
T33441 | |||
MK-789 is an inhibitor of dehydropeptidase I. MK-789 and MK-791 alter the renal excretion of N-formimidoyl thienamycin from glomerular filtration plus tubular secretion to glomerular filtration only, possibly by competitively inhibiting the penetration of | |||
T23939 | |||
DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03329 | DPEP1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I may be a candidate target in PDAC for designing improved treatments. It uses zinc as a cofactor and acts as a disulfide-linked homodimer.
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