目录号 | 产品详情 | 靶点 | |
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T10811 | Others | ||
Chymase-IN-1 是一个有效的,有选择性的,口服有活性的人肥大细胞糜蛋白酶抑制剂,IC50 为 29 nM。 | |||
T12450 | Others | ||
Chymase-IN-2 is a modulator of chymase. | |||
TP1012 | Others | ||
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) 是一种人心脏糜酶 chymase 的短肽类抑制剂。 | |||
TQ0035 | Others | ||
Fulacimstat (BAY1142524) 是可口服的糜酶抑制剂,能够作用于人糜酶(IC50:4 nM)和仓鼠糜酶(IC50:3 nM)。 | |||
T17186 | Others | ||
TY-51469是糜蛋白酶 (chymase) 抑制剂,在类人猿和人糜蛋白酶的 IC50 值分别为0.4和7.0 nM。 | |||
T0577 | Others | ||
通过荧光测定,Chlorobenzothiazolinone 在 1 小时后使用 bis(succinoyl-L-alanyl-L-prolyl-L-phenylalanylamide)作为底物抑制重组人糜酶,活性值为 90 μM。 | |||
T78063 | ERK | ||
Endothelin-1 (1-31) (Human) TFA 是源自chymase对大ET-1选择性水解的一种有效血管收缩剂和血压升高剂。 | |||
T76564 | |||
Endothelin-1 (1-31) (Human) 是源于chymase对大ET-1选择性水解而来的有效血管收缩剂和血压升高剂。 | |||
T23233 | Others | ||
chymase substrate peptide | |||
T28177 | |||
NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02574 | Chymase 1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory processes, although opinions differ as to which AngII-generating enzyme is primarily associated with AngII-mediated effects. ACE in the gastric mucosa and the microvasculature of granulation tissue may represent a novel therapeutic target for the promotion of healing processes in gastritis and ulceration using ACE inhibitors or AT1R antagonists. The gene for mast cell chymase (CMA1) is an ideal candidate for investigating genetic predisposition to atopic asthma, as it is an important mediator of inflammation and remodeling in the asthmatic lung. (CMA1) is important for the generation of angiotensin II and therefore might be associated with the pathogenesis of hypertension.
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TMPH-00486 | Chymase Protein, Canine, Recombinant (His & SUMO) | Canine | E. coli | ||
Chymase Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-02581 | Chymase 1 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared with nanograms of mMCP-2 are detected in peripheral blood during intestinal nematode infection. mMCP-1 isolated from serum is complexed with serpins and both the accumulation and the longevity of mMCP-1 in the blood is due to complex formation, protecting it from a pathway that rapidly clears mMCP-2, which is unable to form complexes with serpins. The mucosal mast cell (MMC) granule-specific beta-chymase, mouse mast cell protease-1 (mMCP-1), is released systemically into the bloodstream early in nematode infection before parasite-specific IgE responses develop and TGF-beta1 induces the constitutive release of mMCP-1 by homologs of MMC in vitro. Expression of mMCP-1 is largely restricted to intraepithelial MMC and is thought to play a role in the regulation of epithelial permeability. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). MCPT-1 is upregulated in the intestine in response to nematode infection, or systemic mucosa in response to anaphylaxis. Like human α-chymase, MCPT-1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure. The intestinal inflammation associated with gastrointestinal helminths is partly mediated by mMCP-1.
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TMPH-03119 | SERPINB1 Protein, Pig, Recombinant (His & Myc) | Sus scrofa (Pig) | E. coli | ||
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.; May be cleaved leading to a loss of its anti-protease activity and to the appearance of an endonuclease activity. However no catalytic site was identified.
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