目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T37071 | Antifungal | ||
Pyrimethanil 是苯胺嘧啶类广谱接触杀菌剂,用于控制多种作物上的Botrytis spp.。它抑制灰霉病菌中氨基酸的生物合成,可用于霉菌感染的水果、蔬菜和观赏植物真菌病害防治的相关研究。 | |||
T3816 | NF-κB HIF/HIF Prolyl-Hydroxylase | ||
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
T8115 | Others | ||
Menthofuran 是一种天然产品。 | |||
TN1576 | IL Receptor NOS NF-κB | ||
Diallyl disulfide 能够抑制人角鲨烯单加氧酶,抑制角鲨烯环氧化的 IC50为 400 μM。它也具有抗肿瘤作用,同miR-200b 和miR-22联合使用可增强该作用。 | |||
TN6715 | Others | ||
7-Ketocholesterol 是胆固醇的代谢物。 | |||
T19859 | Others | ||
Nicosulfuron (Milagro) 是一种磺酰脲类的选择性除草剂,常用作出苗后的除草剂,保护玉米作物免受杂草的侵害。它也能够降低乙酰乳酸合酶的活性。 | |||
T2919 | Others | ||
Sesamin (Fsesamin) 是多不饱和脂肪酸生物合成中的选择性delta 5 去饱和酶抑制剂,是在芝麻油中存在丰富的木脂素。它对脑缺血具有有效的神经保护作用。 | |||
T14362 | Others | ||
AY 9944 是特异性的胆固醇生物合成抑制剂。它抑制 7- 脱氢胆固醇 Δ7- 还原酶 (IC50:13 nM),导致胆固醇不足和 7DHC 积累。在高剂量下,它可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶,造成胆固醇 8-en-3β-ol 的积累。 | |||
TN2331 | Influenza Virus | ||
Eleutheroside B1是具有广谱抗人流感病毒的一种香豆素。它抑制多种趋化因子基因和流感病毒核蛋白基因的 mRNA 表达。它具有抗病毒、抗流感和抗炎活性,且细胞毒性小。 | |||
T20237 | Antifungal | ||
Fenhexamid (Elevate) 是一种甾醇生物合成抑制剂,对植物病原真菌具有抗真菌活性。 Fenhexamid 用于农业,并在水果和蔬菜中以可测量的量存在。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPH-03525 | Cap5A Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | in vitro E. coli expression system | ||
Required for the biosynthesis of type 5 capsular polysaccharide (Cap5/CP5). Might act as the chain-length regulator.
|
|||||
TMPH-00188 | BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) | Bacteroides fragilis | E. coli | ||
BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli.
|
|||||
TMPJ-00932 | PBLD Protein, Human, Recombinant (His) | Human | E. coli | ||
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension.
|
|||||
TMPY-00392 | PAM Protein, Human, Recombinant (His) | Human | HEK293 | ||
Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicellular organisms such as Chlamydomonas reinhardtii, which do not store peptides in secretory granules. As for other granule membrane proteins, PAM is retrieved from the cell surface and returned to the trans-Golgi network. This pathway involves regulated entry of PAM into multivesicular body intralumenal vesicles (ILVs). Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme that catalyzes the COOH-terminal amidation of many neuroendocrine peptides.
|
|||||
TMPY-01736 | COX-2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
|
|||||
TMPY-02801 | PHGDH Protein, Human, Recombinant (His) | Human | E. coli | ||
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PHGDH catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. Overexpression of PHGDH may cause certain breast cancers. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency which is characterized by congenital microcephaly, psychomotor retardation, and seizures.
|
|||||
TMPY-02371 | ST6GAL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Beta-galactoside alpha-2,6-sialyltransferase 1, also known as B-cell antigen CD75, Sialyltransferase 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6GAL1 and SIAT1, is a single-pass type II membrane protein that belongs to the glycosyltransferase 29 family. Sialyltransferases are key enzymes in the biosynthesis of sialoglycoconjugates that catalyze the transfer of sialic residue from its activated form to an oligosaccharidic acceptor. ST6GAL1 / SIAT1 is normally found in the Golgi but can be proteolytically processed to a soluble form. It is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. β-Galactoside α2,6-sialyltransferases ST6GAL1 and ST6GAL2 are the two unique members of the ST6GAL family described in higher vertebrates. ST6GAL1 / SIAT1 transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.
|
|||||
TMPY-03156 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) | Mouse,Rat | HEK293 | ||
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.
|
|||||
TMPY-02779 | Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) | Human | Baculovirus-Insect Cells | ||
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx 100 kDa molecular weight. Thyroid peroxidase is an enzyme expressed abundantly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine or triiodothyronine, thyroid hormones. Thyroid peroxidase plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin to form precursors of the thyroid hormones T4 and T3.
|
|||||
TMPY-01007 | VEGFC Protein, Human, Recombinant (His) | Human | HEK293 | ||
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.
|
|||||
TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipase B that selectively hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lysoNAPEs. ABH4 accepts lysoNAPEs bearing both saturated and polyunsaturated N-acyl chains as substrates and displays a distribution that closely mirrors lysoNAPE-lipase activity in mouse tissues. The existence of an NAPE-PLD-independent route for NAE biosynthesis and suggest that ABH4 plays a role in this metabolic pathway by acting as a (lyso)NAPE-selective lipase.
|
|||||
TMPH-01395 | QPCTL Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Responsible for the biosynthesis of pyroglutamyl peptides.
|
|||||
TMPH-03584 | Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) | Staphylococcus epidermidis | E. coli | ||
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also use NAD to oxidize shikimate.
|
|||||
TMPH-02293 | UGDH Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development.
|
|||||
TMPH-01812 | SEPSECS Protein, Human, Recombinant (His) | Human | Yeast | ||
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
|
|||||
TMPH-00572 | ACP Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
|
|||||
TMPH-02652 | FGF-15 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
|
|||||
TMPH-02958 | Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
|
|||||
TMPH-00591 | SpeA Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Catalyzes the biosynthesis of agmatine from arginine.
|
|||||
TMPH-03453 | GPI3 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | E. coli | ||
Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
|
|||||
TMPH-00563 | 3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
|
|||||
TMPH-03519 | ACP Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | Yeast | ||
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
|
|||||
TMPH-03180 | LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
|
|||||
TMPH-00795 | Glutamate racemase Protein, Helicobacter pylori, Recombinant (His & Myc) | Helicobacter pylori | E. coli | ||
Provides the (R)-glutamate required for cell wall biosynthesis.
|
|||||
TMPH-00564 | FabG Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
|
|||||
TMPH-00020 | Elongation factor Tu Protein, Acinetobacter baumannii, Recombinant (His) | Acinetobacter baumannii | Yeast | ||
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
|
|||||
TMPH-03520 | ACP Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
|
|||||
TMPH-03402 | STR1 Protein, Rauvolfia serpentina, Recombinant (His & Myc) | Rauvolfia serpentina | E. coli | ||
Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
|
|||||
TMPH-01813 | SEPSECS Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
|
|||||
TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli | ||
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
|
|||||
TMPH-03179 | LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
|
|||||
TMPH-02378 | LpxC Protein, Klebsiella pneumoniae, Recombinant (His & Myc) | Klebsiella pneumoniae | E. coli | ||
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
|
|||||
TMPJ-01265 | PPC-DC Protein, Human, Recombinant (aa 1-204, His) | Human | E. coli | ||
Phosphopantothenoylcysteine Decarboxylase (PPC-DC) is an essential enzyme in the biosynthesis ofCoenzyme A and catalyzes the decarboxylation of PPC to Phosphopantetheine. PPC-DC catalyzes the decarboxylation of the Cysteine moiety of 4-Phosphopantothenoylcysteine (PPC) to form 4-Phosphopantetheine (PPantSH), this reaction forms part of the biosynthesis of Coenzyme A. The enzyme is a member of the larger family of Cysteine Decarboxylases including the Lantibiotic-Biosynthesizing enzymes EpiD and MrsD, all of which use a tightly bound Flavin cofactor to oxidize the Thiol moiety of the substrate to a Thioaldehyde.
|
|||||
TMPH-02491 | SCD1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea.
|
|||||
TMPH-00602 | MetC Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. Also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine. In addition, under certain growth conditions, exhibits significant alanine racemase coactivity.
|
|||||
TMPY-01948 | COQ7 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which belongs to theCOQ7 family. It is expressed dominantly in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. This enzyme is responsible for the hydroxylation of 5-demethoxyubiquinone to 5-hydroxyubiquinone. Human COQ7 protein is mostly helical, and contains an alpha-helical membrane insertion. It has a potential N-glycosylation site, a phosphorylation site for protein kinase C and another for casein kinase II, and three N-myristoylation sites. COQ7 is involved in lifespan determination in ubiquinone-independent manner. It is also involved in ubiquinone biosynthesis. COQ7 is potential central metabolic regulator.
|
|||||
TMPY-03507 | PPC-DC Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by phosphopantetheine adenylyltransferase to form dephospho-CoA and the phosphorylation by dephospho-CoA kinase to form CoA. PPC-DC, one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine.
|
|||||
TMPY-00481 | AKR1C4 Protein, Human, Recombinant (His) | Human | E. coli | ||
Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism.
|
|||||
TMPY-03810 | GALNT2 Protein, Human, Recombinant (His) | Human | HEK293 | ||
GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. GALNT2 may play a role in lipid metabolism. It catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT2 has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b.
|
|||||
TMPH-00019 | BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) | Acinetobacter baumannii | E. coli | ||
|
|||||
TMPH-03048 | LpxA Protein, MenC, Recombinant (His) | MenB | E. coli | ||
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
|
|||||
TMPH-03518 | ACP Protein, S. aureus, Recombinant (GST) | Staphylococcus aureus | E. coli | ||
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
|
|||||
TMPH-02679 | QPCT Protein, Mouse, Recombinant (His) | Mouse | Yeast | ||
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
|
|||||
TMPH-00691 | IscS Protein, E. coli O6:K15:H31, Recombinant (His & Myc & SUMO) | E. coli | E. coli | ||
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
|
|||||
TMPH-00648 | LapB Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
|
|||||
TMPH-00555 | LpxC Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
|
|||||
TMPH-00024 | LpxC Protein, Acinetobacter baumannii, Recombinant (His) | Acinetobacter baumannii | E. coli | ||
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
|
|||||
TMPY-06352 | ALDH1A3 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.
|
|||||
TMPH-01007 | NDST1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan.
|
|||||
TMPH-00318 | LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) | Burkholderia pseudomallei | E. coli | ||
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
|