目录号 | 产品详情 | 靶点 | |
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T12746 | ROCK | ||
ROCK inhibitor-2 是一种 ROCK1和 ROCK2的选择性双重抑制剂,IC50值分别为 17 nM 和2 nM。 | |||
T13419 | ROCK | ||
ROCK-IN-1 是一种高效的 ROCK 抑制剂,对 ROCK2 介导的信号传导有抑制作用,IC50 值为 1.2 nM。ROCK-IN-1 可用于研究神经系统疾病和炎症相关疾病。 | |||
T67748 | ROCK ERK | ||
ROCK-IN-5(化合物I-B-37)是一种有效的蛋白激酶抑制剂,包括ROCK、ERK、GSK 和AGC。ROCK-IN-5在心脏病、增殖性疾病和神经退行性疾病研究方面具有潜力。 | |||
TQ0110 | ROCK | ||
ROCK-IN-2 (Azaindole 1) 是一种选择性,ATP-竞争型的ROCK 抑制剂,对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。 | |||
T12747 | ROCK | ||
ROCK2-IN-2 是 ROCK2 的特异性抑制剂(IC50 <1 μM)。 | |||
T4095 | ROCK | ||
ZINC00881524 (ROCK inhibitor)是一种特异性有效 ROCK 抑制剂。 | |||
T24725 | |||
ROCK-IN-D3 is an effective and selective inhibitor of ROCK. | |||
T24724 | |||
ROCK-IN-D2 is an effective and selective inhibitor of ROCK. | |||
T24723 | |||
ROCK-IN-D1 is an effective and selective inhibitor of ROCK. | |||
T24722 | |||
ROCK-IN-32 is an effective Rho-kinase inhibitor. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-03265 | CMKLR2 Protein, Rat, Recombinant (His) | Rat | in vitro E. coli expression system | ||
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.
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TMPH-01805 | ODAM Protein, Human, Recombinant (His) | Human | E. coli | ||
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
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TMPH-02697 | GNA12 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
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