T72188
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Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式,可抑制SIRT2的体外活性,其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量,并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率,可用于黑色素瘤等皮肤癌相关的研究。 |
T69395
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Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing. |
T67925
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NAMPT
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NAMPT activator-1 (compound 1) 是一种有效的、专用范围广泛的烟酰胺磷酸基转移酶 (NAMPT) 激活剂(EC50 为3.3-3.7 μM)。NAMPT activator-1能有效保护培养细胞免受 fk866介导的毒性,是神经保护的潜在化合物。 |
T0879
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Endogenous Metabolite
Autophagy
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Niacin (Nicotinic acid),也称为烟酸和维生素 B3,是一种水溶性必需的 B 族维生素,用于治疗维生素缺乏症以及高脂血症,血脂异常,高甘油三酯血症,并降低心肌梗塞的风险 |
T9540
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Dopamine Receptor
Serotonin Transporter
Norepinephrine
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Phenelzine 是一种抗抑郁和躁狂症药物,是一种单胺氧化酶抑制剂。其抗抑郁作用与烟酰胺相似。可减少脑内儿茶酚胺(去甲肾上腺素、多巴胺、5-羟色胺)的降解,增加儿茶酚胺的含量。 ,并起到抗抑郁作用。对内源性抑郁症疗效较好,对外源性和反应性抑郁症疗效较差。 |