目录号 | 产品详情 | 靶点 | |
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T8816 | Apoptosis E1/E2/E3 Enzyme | ||
NAE-IN-M22 (NEDD8 inhibitor M22) 是一种选择性可逆的 NEDD8 激活酶抑制剂。 它抑制多种癌细胞系并诱导 A549 细胞凋亡,还可以在体内抑制肿瘤生长。 | |||
T6332 | E1/E2/E3 Enzyme NEDD8 | ||
Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM),具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗,也具有抗肿瘤活性。 | |||
T13090 | E1/E2/E3 Enzyme NEDD8 | ||
TAS4464 hydrochloride 是高效的、选择性的 NEDD8 活化酶 (NAE)抑制剂,其 IC50=0.955 nM。 | |||
T5374 | E1/E2/E3 Enzyme NEDD8 | ||
NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂,可以抑制 DCN1-UBE2M 相互作用。 | |||
T13412 | E1/E2/E3 Enzyme | ||
ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。 | |||
T16102 | E1/E2/E3 Enzyme | ||
ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2,IC50分别为 3 和 11 nM,对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱,IC50分别为 32 μM 和 >100 μM。 | |||
T63800 | |||
ZM223 hydrochloride 是有效的、非共价的、口服具有活力的 NEDD8 活化酶 (NAE) 抑制剂。 | |||
T68059 | |||
NAE-086 是一种高亲和力和选择性的5-HT(1A)受体配体,其K(i)值为4.5 nM。 | |||
T69577 | |||
LEI-301 is a novel potent inhibitor for the PLAAT family members, reducing the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5. | |||
T13412L | Serine Protease | ||
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipase B that selectively hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lysoNAPEs. ABH4 accepts lysoNAPEs bearing both saturated and polyunsaturated N-acyl chains as substrates and displays a distribution that closely mirrors lysoNAPE-lipase activity in mouse tissues. The existence of an NAPE-PLD-independent route for NAE biosynthesis and suggest that ABH4 plays a role in this metabolic pathway by acting as a (lyso)NAPE-selective lipase.
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