目录号 | 产品详情 | 靶点 | |
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T24133 | HDAC | ||
HDAC8-IN-20a (HDAC8 inhibitor-20a) 是一种有效的、具有选择性的HDAC8抑制剂,IC50为27 nM。HDAC8-IN-20a 可阻断生长受体存活信号的激活。 | |||
T7082 | HDAC | ||
HDAC8-IN-1 是一种 HDAC8 抑制剂,在癌细胞系中的 IC50 为 27.2 nM,有抗增殖作用。 | |||
T13996 | HDAC | ||
1-Naphthohydroxamic acid 是一种选择性 HDAC8抑制剂,IC50为 14 μM。它对 HDAC8的选择性高于 I 类 HDAC1 和 II 类 HDAC6,IC50大于100 μM,可诱导微管蛋白乙酰化。 | |||
T6481 | Apoptosis HDAC | ||
Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂,IC50分别为16.9、2.47和1.46 μM。 | |||
T62171 | |||
HDAC8/BRPF1-IN-1 (Compound 23a) 是一种双重的 HDAC8 和 BRPF1 抑制剂,能够作用于人 HDAC8 (IC50: 443 nM)、人 BRPF1 (Kd: 67 nM)。 HDAC8/BRPF1-IN-1 对 HDAC1 和 6 具有较低的体外活性。 | |||
T79082 | HDAC | ||
HDAC8-IN-4为HDAC8特异性抑制剂,对HDAC8及HDAC3具有抑制活性,IC50s值分别为0.15 μM与12 μM。 | |||
T61549 | |||
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 μM and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and greatly reduces egg laying in adult worm pairs [1]. | |||
T61858 | |||
HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in leukemic cell lines [1]. | |||
T78861 | HDAC | ||
HDAC8-IN-5 (Compound 6a),一种HDAC8抑制剂,其半抑制浓度(IC50)为28 nM。该化合物主要适用于癌症研究领域。 | |||
T6421 | HDAC | ||
BRD73954 是一种有效且特异性的 HDAC 抑制剂,对 HDAC6 和 HDAC8 的 IC50 分别为 36 nM 和 120 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02317 | HDAC8 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells | ||
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It is expressed at a higher level in the heart, brain, kidney, and pancreas and also in the liver, lung, placenta, prostate, and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3, and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.
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TMPY-01333 | HDAC8 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells | ||
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It is expressed at a higher level in the heart, brain, kidney, and pancreas and also in the liver, lung, placenta, prostate, and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3, and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.
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