目录号 | 产品详情 | 靶点 | |
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TP2047L | CRFR | ||
CRF (6-33) acetate(120066-38-8 free base) 是促肾上腺皮质激素释放因子结合蛋白 (CRFBP) 抑制肽;从 CRFBP 中替换 CRF。在体内抑制肥胖大鼠的体重增加并增加运动活动。 | |||
TP2048L | CRFR | ||
α-helical CRF 9-41 acetate 是 CRF2 的竞争性拮抗剂 (KB = 100 nM) 和 CRF1 的部分激动剂 (EC50 = 140 nM)。 | |||
TP2047 | |||
Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo. | |||
TP1191 | |||
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM. | |||
TP2048 | |||
Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively). | |||
TP1190 | |||
CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8 | |||
T75972 | |||
CRF, bovine (TFA) 是一种有效的CRF 受体激动剂,能够取代 [125I-Tyr]ovine CRF,Ki 值为 3.52 nM。 | |||
TP1144 | |||
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b | |||
T12276 | Others | ||
NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1). | |||
T83665 | |||
α-Helical CRF (9-41) 是一种合成的皮质酮释放因子(CRF)拮抗剂。它在0.5至5 µM浓度范围内,能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素(ACTH)。在体内研究中,α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放,并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外,α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间,并减少小鼠的类似暴饮暴食的乙醇消费。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00906 | CRHBP Protein, Human, Recombinant (His) | Human | Human Cells | ||
Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.
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TMPY-01373 | HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His) | HIV | HEK293 | ||
The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
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TMPY-03412 | GGCT Protein, Human, Recombinant (His) | Human | E. coli | ||
GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in glutathione homeostasis. GGCT also induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Pseudogenes of GGCT gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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TMPY-02882 | HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His) | HIV | HEK293 | ||
HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His) is expressed in HEK293 with His tag. The predicted molecular weight is 78.2 kDa.
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TMPH-02608 | Corticoliberin Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli | ||
Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
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TMPH-02555 | C1QL1 Protein, Mouse, Recombinant (His) | Mouse | Yeast | ||
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.
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TMPY-01408 | HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc) | HIV | HEK293 | ||
HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc) is expressed in HEK293 with Fc tag. The predicted molecular weight is 98 kDa.
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TMPY-06486 | HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated | HIV | HEK293 | ||
The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
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TMPY-04061 | HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) | HIV | E. coli | ||
HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) is expressed in E. coli with His and MBP tag. The predicted molecular weight is 58.8 kDa. Accession number: L8B302
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TMPK-00474 | IL-22RA1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 | ||
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
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