T6S2227
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Others
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Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 |
TP1007L
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β-Amyloid (1-42), acetate (human) 是由 42 个氨基酸组成的肽,是 β-Amyloid 的一部分,常用于阿尔茨海默病造模。 |
T61388
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hAChE/Aβ1-42-IN-1 (Compound 16) 是一种有效的 hAChE 和 Aβ1-42聚集抑制剂。hAChE/Aβ1-42-IN-1 对 hepG2 细胞系显示出可接受的相对安全性,并具有良好的 BBB 渗透性和较宽的安全范围。hAChE/Aβ1-42-IN-1具有研究阿尔茨海默病 (AD) 的潜力。 |
T60940
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ChE/Aβ1-42-IN-1 (compound 28) 是一种有效的ChE 和Aβ1-42聚集抑制剂,具有良好的血脑屏障通透性。ChE/Aβ1-42-IN-1 对 AChE、BuChE 和 Aβ1-42聚集的IC50值分别为 0.062、0.767和1.227 μM。ChE/Aβ1-42-IN-1 是一种有效的多靶点抗阿尔茨海默病剂。 |
T64238
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Aβ1-42 aggregation inhibitor 1 抑制乙酰胆碱酯酶 AChE 和丁酰胆碱酯酶 BuChE 的 IC50值分别为 2.64 μM 和 1.29 μM。Aβ1-42 aggregation inhibitor 1 是一种可以自身介导的Aβ1-42聚集抑制剂,在浓度为 25 μM 抑制 51.29%。Aβ1-42 aggregation inhibitor 1 可用于抗阿尔兹海默症的研究。 |
T35499
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β-Amyloid (1-42), (rat/mouse) (TFA) 是由 42 个氨基酸组成的多肽片段,可用于研究阿尔茨海默症。 |
T37367
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Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4
1.Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11)859-866(2002) 2.Iwatsubo, T., Odaka, A., Suzuki, N., et al.Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron13(1)45-53(1994) 3.Hardy, J.A., and Higgins, G.A.Alzheimer's disease: The amyloid cascade hypothesisScience256(5054)184-185(1992) 4.Jankowsky, J.L., and Zheng, H.Practical considerations for choosing a mouse model of Alzheimer's diseaseMol. Neurodegener.12(1)89(2017) |
T37472
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TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers. TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively. |
T37200
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Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in rat hippocampal synaptosomal membranes. |
T76425
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(Glu20)-Amyloid β-Protein (1-42) 是淀粉样蛋白 β-蛋白 (Aβ) 的一种较慢原纤维化变体。Glu20 突变降低了 Aβ 的聚集倾向,从而防止缓慢原纤化肽的积累。β 淀粉样蛋白是阿尔茨海默病中血管和实质淀粉样沉积物的主要成分。 |