Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 180 | 5日内发货 | ||
50 μg | ¥ 660 | 5日内发货 | ||
500 μg | ¥ 2,760 | 5日内发货 | ||
1 mg | ¥ 3,950 | 5日内发货 |
产品描述 | Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. |
种属 | Human |
表达系统 | E. coli |
标签 | N-GST |
蛋白编号 | P51668 |
别名 | Ubiquitin-conjugating enzyme E2(17)KB 1, UB, UbcH5, UBC5A, Stimulator of Fe transport, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2-17 kDa 1, UBC4/5 homolog, Ubiquitin-conjugating enzyme E2 D1, Ubiquitin-protein ligase D1, SFT |
氨基酸序列 | Met1-Met147 |
蛋白构建 | Recombinant Human Ubiquitin-conjugating Enzyme E2 D1 is produced by our E.coli expression system and the target gene encoding Met1-Met147 is expressed with a GST tag at the N-terminus. |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 40 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. |
存储 |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
运输方式 |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. |
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UBE2D1 Protein, Human, Recombinant (GST) Ubiquitin-conjugating enzyme E2(17)KB 1 UB UbcH5 UBC5A Stimulator of Fe transport Ubiquitin carrier protein D1 Ubiquitin-conjugating enzyme E2-17 kDa 1 UBC4/5 homolog Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-protein ligase D1 SFT recombinant recombinant-proteins proteins protein