TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

规格	价格/CNY		数量
10 μg	￥ 1,170	现货
50 μg	￥ 3,470	5日内发货
500 μg	￥ 15,000	5日内发货
1 mg	￥ 24,100	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 1,170

现货

50 μg

￥ 3,470

5日内发货

500 μg

￥ 15,000

5日内发货

1 mg

￥ 24,100

5日内发货

生物活性

Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is 10-80 pg/ml. (QC verified)

TargetMol Bioactive

产品描述

种属	Human,Mouse,Rat
表达系统	Human Cells
标签	None
蛋白编号	P10600
别名	Latency-associated peptide, TGF-beta-3, Transforming growth factor beta-3, TGFB3, TGF-β-3, LAP, Transforming growth factor β-3
氨基酸序列	Ala301-Ser412(Tyr340Phe)
蛋白构建	Recombinant Human/Mouse/Rat Transforming Growth Factor Beta 3 is produced by our Mammalian expression system and the target gene encoding Ala301-Ser412(Tyr340Phe) is expressed.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	12-14 KDa, reducing conditions

内毒素	Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

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TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

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