SEMA7A Protein, Mouse, Recombinant (His)

Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.

规格	价格/CNY		数量
100 μg	￥ 2,140	5日内发货
500 μg	￥ 8,600	5日内发货
1 mg	￥ 14,300	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 2,140

5日内发货

500 μg

￥ 8,600

5日内发货

1 mg

￥ 14,300

5日内发货

产品描述

种属	Mouse
表达系统	HEK293
标签	C-His
蛋白编号	Q9QUR8
别名	Sema7A, H-SEMA-K1, JMH, Semaphorin-K1, Semaphorin-L, CD108, H-Sema-L, SEMAK1, MGC126692, CD108MGC126696, SEMAL, CDw108, Sema L, Semaphorin-7A
蛋白构建	Recombinant Mouse SEMA7A Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln45-Ala646.[Accession \|Q9QUR8]
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	The protein has a predicted MW of 69.5 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.