SEMA3A Protein, Human, Recombinant (hFc)

Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease

规格	价格/CNY		数量
50 μg	￥ 2,520	现货
100 μg	￥ 4,320	5日内发货
200 μg	￥ 7,380	5日内发货
500 μg	￥ 14,930	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,520

现货

100 μg

￥ 4,320

5日内发货

200 μg

￥ 7,380

5日内发货

500 μg

￥ 14,930

5日内发货

生物活性

Testing in progress

产品描述

种属	Human
表达系统	HEK293
标签	hFc
蛋白编号	Q14563
别名	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, COLL1, SEMAD, Hsema-I, Semaphorin 3A, SEMAIII, SEMAL, HH16, SEMA1, coll-1, Hsema-III, SemD
蛋白构建	A DNA sequence encoding the human SEMA3A (NP_006071.1) (Lys26-Phe546) was expressed with the Fc region of human IgG1 at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	Approxiamtely 87.7 kDa

内毒素	< 1.0 EU per μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease