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S100A8 Protein, Mouse, Recombinant (His)

产品编号 TMPY-03556

别名: p8, S100 calcium binding protein A8, Caga, 60B8Ag, B8Ag, CFAg, CP-10, MRP8, AI323541

S100A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P27005.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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S100A8 Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,170		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	S100A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P27005.

种属	Mouse
表达系统	E. coli
标签	His
蛋白编号	P27005
别名	p8, S100 calcium binding protein A8, Caga, 60B8Ag, B8Ag, CFAg, CP-10, MRP8, AI323541
蛋白构建	A DNA sequence encoding the mouse S100a8 (P27005) (Pro2-Glu89) was expressed, with a polyhistidine tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	12.3 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Supplied as sterile 50mM Tris, 100mM NaCl, 20% Glycerol, pH 8.0. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	Solution. It is shipped out with blue ice.
研究背景	S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and cancer suggest that S100A8/A9 may play a key role in inflammation-associated cancer.

参考文献

1. Passey RJ,et al.(1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56. 2. Gebhardt C,et al.(2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31. 3. Halayko AJ,et al.(2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55. 4. Ghavami S,et al.(2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83. 5. Ha YS,et al.(2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.

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Keywords

S100A8 Protein, Mouse, Recombinant (His) p8 MRP-8 S100 calcium binding protein A8 Caga CP 10 AI 323541 60B8Ag AI-323541 B8Ag CFAg CP-10 MRP 8 MRP8 CP10 AI323541 recombinant recombinant-proteins proteins protein

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