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PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

产品编号 TMPY-02511
别名: LRP, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), HPTPA, R-PTP-α, HEPTP, protein tyrosine phosphatase, receptor type, A, HPTPalpha, HPTPα, RPTPA, PTPRL2, HLPR, PTPA, R-PTP-alpha

PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

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PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 5日内发货
500 μg ¥ 24,900 5日内发货
千万补贴 助力科研
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产品目录号及名称: PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) (TMPY-02511)
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生物活性
技术参数
产品性质
参考文献
生物活性 1. Measured by its ability to bind biotinylated recombinant mouse SRC in a functional ELISA. 2. Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >40000 pmol/min/μg.
产品描述 PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.
种属 Human
表达系统 Baculovirus-Insect Cells
标签 His,GST
蛋白编号 P18433-2
别名 LRP, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), HPTPA, R-PTP-α, HEPTP, protein tyrosine phosphatase, receptor type, A, HPTPalpha, HPTPα, RPTPA, PTPRL2, HLPR, PTPA, R-PTP-alpha
蛋白构建 A DNA sequence encoding the human PTPRA isoform 2 (P18433-2) cytoplasmic domain (Ala 174-Lys 793) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
蛋白纯度 > 90 % as determined by SDS-PAGE
分子量 99 kDa (predicted)
内毒素 < 1.0 EU per μg of the protein as determined by the LAL method
缓冲液 Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 3mM DTTPlease contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法 A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
存储

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

运输方式

Solution. It is shipped out with blue ice.

研究背景 PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

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Keywords

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) LRP PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) HPTPA R-PTP-α HEPTP protein tyrosine phosphatase, receptor type, A HPTPalpha HPTPα RPTPA PTPRL 2 PTPRL2 HLPR PTPA PTPRL-2 R-PTP-alpha recombinant recombinant-proteins proteins protein

 

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