Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. Two distinct domains of PSG1 are involved in the regulation of TGF-beta1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome.
生物活性 | Testing in progress |
产品描述 | Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. Two distinct domains of PSG1 are involved in the regulation of TGF-beta1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome. |
种属 | Human |
表达系统 | HEK293 |
标签 | His |
蛋白编号 | P11464-1 |
别名 | PS-β-G-1, PSBG-1, PS-beta-G-1, CD66f, pregnancy specific β-1-glycoprotein 1, B1G1, DHFRP2, FL-NCA-1/2, PSGGA, pregnancy specific beta-1-glycoprotein 1, PS-beta-C/D, PS-β-C/D, PSBG1, PBG1, SP1, PSG95, PSGIIA |
蛋白构建 | A DNA sequence encoding the human PSG1 (NP_001171754.1) (Met1-Pro419) was expressed with a polyhistidine tag at the C-terminus. |
蛋白纯度 | > 95 % as determined by SDS-PAGE. |
分子量 | 44.9 kDa (predicted) |
内毒素 | < 1.0 EU per μg protein as determined by the LAL method. |
缓冲液 | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
复溶方法 | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
存储 |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. Two distinct domains of PSG1 are involved in the regulation of TGF-beta1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome. |
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PSG1 Protein, Human, Recombinant (His) PS-b-G-1 SP-1 PS-β-G-1 DHFRP-2 PSBG-1 PS-beta-G-1 PBG 1 PSBG 1 CD66f pregnancy specific β-1-glycoprotein 1 B1G1 PBG-1 DHFRP2 FL-NCA-1/2 PSGGA SP 1 pregnancy specific beta-1-glycoprotein 1 PS-b-C/D PSG 95 pregnancy specific b-1-glycoprotein 1 PS-beta-C/D DHFRP 2 PS-β-C/D PSBG1 PBG1 SP1 PSG95 PSG-95 PSGIIA recombinant recombinant-proteins proteins protein