Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 1,170 | 5日内发货 | ||
50 μg | ¥ 3,470 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 17,400 | 5日内发货 |
产品描述 | Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients. |
种属 | Human |
表达系统 | E. coli |
标签 | N-6xHis |
蛋白编号 | P61457 |
别名 | 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase, Pterin-4-α-Carbinolamine Dehydratase, Phenylalanine Hydroxylase-Stimulating Protein, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha, PHS, Dimerization Cofactor of HNF1, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α, 4-α-Hydroxy-Tetrahydropterin Dehydratase, DCoH, Pterin Carbinolami, Pterin-4-Alpha-Carbinolamine Dehydratase |
氨基酸序列 | Ala2-Thr104 |
蛋白构建 | Ala2-Thr104 |
分子量 | 14 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, pH 8.0. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients. |
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PHS Protein, Human, Recombinant (His) 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase Pterin-4-α-Carbinolamine Dehydratase Phenylalanine Hydroxylase-Stimulating Protein Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha PHS Dimerization Cofactor of HNF1 Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α 4-α-Hydroxy-Tetrahydropterin Dehydratase 4-a-Hydroxy-Tetrahydropterin Dehydratase DCoH Pterin-4-a-Carbinolamine Dehydratase Pterin Carbinolami Pterin-4-Alpha-Carbinolamine Dehydratase recombinant recombinant-proteins proteins protein