PFKFB3 Protein, Human, Recombinant (His)

Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.

规格	价格/CNY		数量
10 μg	￥ 750	5日内发货
50 μg	￥ 2,260	5日内发货
500 μg	￥ 12,100	5日内发货
1 mg	￥ 18,300	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 750

5日内发货

50 μg

￥ 2,260

5日内发货

500 μg

￥ 12,100

5日内发货

1 mg

￥ 18,300

5日内发货

产品描述

种属	Human
表达系统	E. coli
标签	N-6His
蛋白编号	Q16875
别名	PFK/FBPase 3, PFK2, IPFK2, iPFK-2
氨基酸序列	Met1-His520
蛋白构建	Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 is produced by our E.coli expression system and the target gene encoding Met1-His520 is expressed with a 6His tag at the N-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	57-62 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Supplied as a 0.2 μm filtered solution of 20mM PB, 50mM KCl, 5mM DTT, 0.1mM EDTA, 50% glycerol, 0.1% TritonX-100, pH 6.0.
存储	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输方式	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
研究背景	Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.

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PFKFB3 Protein, Human, Recombinant (His)

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