PD-L1 Protein, Cynomolgus, Recombinant (His)

PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.

规格	价格/CNY		数量
10 μg	￥ 700	5日内发货
50 μg	￥ 1,970	5日内发货
500 μg	￥ 9,960	5日内发货
1 mg	￥ 14,200	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 700

5日内发货

50 μg

￥ 1,970

5日内发货

500 μg

￥ 9,960

5日内发货

1 mg

￥ 14,200

5日内发货

生物活性	1. Loaded Cynomolgus PD-L1-His on HIS1K Biosensor, can bind Anti-Human PDL1 mAb-Fc with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Anti-Human PDL1 mAb-Fc at 2μg/ml (100 μl/well)can bind Cynomolgus PD-L1-His. The ED50 of Cynomolgus PD-L1-His is 67.12 ng/ml. (Regularly tested)
产品描述	PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.

种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	G7PSE7
别名	B7-H, B7-H1, PDL1, PDCD1L1, PDL1PDCD1 ligand 1, CD274 antigenMGC142294, PDCD1LG1, Programmed death ligand 1, PD-L1B7 homolog 1, CD274 molecule, CD274, PD-L1, programmed cell death 1 ligand 1, B7H1, B7H1PDCD1L1
氨基酸序列	Phe19-Thr239
蛋白构建	Phe19-Thr239
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	32-40 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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PD-L1 Protein, Cynomolgus, Recombinant (His)

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