OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-50 KDa and the accession number is XM_005545122.1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 1,170 | 5日内发货 | ||
50 μg | ¥ 3,470 | 5日内发货 | ||
500 μg | ¥ 13,200 | 5日内发货 | ||
1 mg | ¥ 18,900 | 5日内发货 |
生物活性 | Loaded Biotinylated Cynomolgus OX40-His on HIS1K Biosensor, can bind Human OX40L-mFc with an affinity constant of 0.05nM as determined in BLI assay. (Regularly tested) |
产品描述 | OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-50 KDa and the accession number is XM_005545122.1. |
种属 | Cynomolgus |
表达系统 | HEK293 Cells |
标签 | C-6xHis |
蛋白编号 | XM_005545122.1 |
别名 | CD134, Tnfrsf4, Txgp1, OX40, Tumor necrosis factor receptor superfamily member 4 |
氨基酸序列 | Lys28-Ala214 |
蛋白构建 | Lys28-Ala214 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 35-50 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases. |
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OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His) CD134 Tnfrsf4 Txgp1 OX40 OX 40 Tumor necrosis factor receptor superfamily member 4 OX-40 CD 134 CD-134 recombinant recombinant-proteins proteins protein