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METAP2 Protein, Human, Recombinant (His)

产品编号 TMPY-00018

别名: MAP2, MNPEP, p67eIF2, methionyl aminopeptidase 2, p67

METAP2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is A0A140VJE3.

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METAP2 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 5,100		5日内发货

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参考文献

生物活性	Measure by its ability to remove methionine from a fluorogenic peptide substrate H-Met-Gly-Pro-AMC . The resulting GP-AMC is cleaved by Recombinant Human DPPIV/CD26 . The specific activity is >15 pmol/min/µg.
产品描述	METAP2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is A0A140VJE3.

种属	Human
表达系统	Baculovirus-Insect Cells
标签	His
蛋白编号	A0A140VJE3
别名	MAP2, MNPEP, p67eIF2, methionyl aminopeptidase 2, p67
蛋白构建	A DNA sequence encoding the human METAP2 (NP_006829.1) (Met1-Tyr478) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE.
分子量	54.3 kDa (predicted)

内毒素	< 1.0 EU per μg protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
存储	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	Solution. It is shipped out with blue ice.
研究背景	METAP2 (Methionine aminopeptidase 2), also known as MAP2 is a protein that belongs to the peptidase M24A family. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. The catalytic activity of human MAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.

参考文献

1. Bennett,et al.(1997) EPR Studies on the Mono- and Dicobalt (II)-Substituted Forms of the Aminopeptidase from Aeromonas proteolytica. Insight into the Catalytic Mechanism of Dinuclear Hydrolases. J Am Chem Soc. 119:1923-33. 2. Johansson,et al.(2008) Dicobalt II-II, II-III, and III-III Complexes as Spectroscopic Models for Dicobalt Enzyme Active Sites. Inorg Chem. 47:5079-92. 3. Bradshaw,et al.(2002) Aminopeptidases and angiogenesis. Essays Biochem. 38: 5-78.

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Keywords

METAP2 Protein, Human, Recombinant (His) MAP2 MNPEP MAP-2 p67eIF2 MAP 2 methionyl aminopeptidase 2 p67 recombinant recombinant-proteins proteins protein

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