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MCP-2 Protein, Mouse, Recombinant (His & NusA)

产品编号 TMPY-02104

别名: MCP-2, Mcp2, chemokine (C-C motif) ligand 8, HC14, 1810063B20Rik, Scya8, AB023418

MCP-2 Protein, Mouse, Recombinant (His & NusA) is expressed in E. coli expression system with His and NusA tag. The predicted molecular weight is 66 kDa and the accession number is Q9Z121.

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MCP-2 Protein, Mouse, Recombinant (His & NusA)

规格	价格/CNY		货期	数量
50 μg	￥ 2,440		现货
1 mg	￥ 25,600		5日内发货

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生物活性	Testing in progress
产品描述	MCP-2 Protein, Mouse, Recombinant (His & NusA) is expressed in E. coli expression system with His and NusA tag. The predicted molecular weight is 66 kDa and the accession number is Q9Z121.

种属	Mouse
表达系统	E. coli
标签	His, NusA
蛋白编号	Q9Z121
别名	MCP-2, Mcp2, chemokine (C-C motif) ligand 8, HC14, 1810063B20Rik, Scya8, AB023418
蛋白构建	The mature form of Mouse CCL8 (Q9Z121) (Gly 24-Pro 94) was fused with the polyhistidine-tagged NusA tag at the N-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	66 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.

参考文献

1. Laing KJ,et al.(2004) Chemokines. Developmental and comparative immunology. 28 (5): 443-60. 2. Cocchi F,et al.(1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+T cells. Science. 270 (5243): 1811–5. 3. Hori T,et al.(2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood. 111 (8): 4403-12. 4. Biber K,et al.(2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Journal of Leukocyte Biology. 74 (2): 243-51.

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Keywords

MCP-2 Protein, Mouse, Recombinant (His & NusA) MCP-2 Mcp2 AB-023418 chemokine (C-C motif) ligand 8 MCP 2 HC14 HC 14 HC-14 1810063B20Rik Scya8 AB023418 AB 023418 recombinant recombinant-proteins proteins protein

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