LGMN Protein, Human, Recombinant (His)

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

规格	价格/CNY		数量
100 μg	￥ 2,360	5日内发货
500 μg	￥ 9,490	5日内发货
1 mg	￥ 15,800	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 2,360

5日内发货

500 μg

￥ 9,490

5日内发货

1 mg

￥ 15,800

5日内发货

产品描述

种属	Human
表达系统	HEK293
标签	N-His
蛋白编号	Q99538-1
别名	AI746452, Legumain, LGMN1, Prsc1, AEP, LGMN, AU022324
蛋白构建	Recombinant Human LGMN Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Val18-Tyr433.[Accession \|Q99538-1]
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Supplied as 0.22μm filtered solution in PBS (pH 7.4).
存储	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.