LAIR1 Protein, Human, Recombinant (His & Avi)

LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.

规格	价格/CNY		数量
100 μg	￥ 2,960	5日内发货
500 μg	￥ 11,800	5日内发货
1 mg	￥ 19,700	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 2,960

5日内发货

500 μg

￥ 11,800

5日内发货

1 mg

￥ 19,700

5日内发货

生物活性

1. Immobilized Human LAIR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 15.3ng/ml determined by ELISA. 2. Human LAIR1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Native Human Collagen I protein with an affinity constant of 0.082 nM as determined in SPR assay.

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	Q6GTX8-1
别名	CD305, LAIR1, LAIR-1, HLAIR1
蛋白构建	Gln22-His163
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	18.2 kDa (predicted). Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.

内毒素	< 1 EU/μg by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.