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KLRG1 Protein, Mouse, Recombinant (hFc)

产品编号 TMPK-00750

别名: 2F1, MAFA, MGC13600, CLEC15A, CLEC15AMAFA-LIKE, KLRG1, MAFAL

KLRG1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 42.3 kDa and the accession number is O88713.

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KLRG1 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,100		5日内发货
500 μg	￥ 12,400		5日内发货
1 mg	￥ 20,700		5日内发货

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参考文献

产品描述	KLRG1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 42.3 kDa and the accession number is O88713.

种属	Mouse
表达系统	HEK293
标签	N-hFc
蛋白编号	O88713
别名	2F1, MAFA, MGC13600, CLEC15A, CLEC15AMAFA-LIKE, KLRG1, MAFAL
蛋白构建	Recombinant Mouse KLRG1 Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Gln57-Tyr188.[Accession \|O88713]
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	The protein has a predicted MW of 42.3 kDa. Due to glycosylation, the protein migrates to 43-50 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.

参考文献

1. Meinicke H, et al. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Immunology. 2017 Sep;152(1):65-73. doi: 10.1111/imm.12749. Epub 2017 Jun 20. PMID: 28437578; PMCID: PMC5543461.

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Keywords

KLRG1 Protein, Mouse, Recombinant (hFc) 2F1 MGC-13600 MAFA KLRG-1 MGC13600 CLEC15A CLEC15AMAFA-LIKE KLRG 1 KLRG1 MAFAL MGC 13600 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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