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Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His)

Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His)

产品编号 TMPJ-00544
别名: PRSS6, Serine Protease 6, hK7, Stratum Corneum Chymotryptic Enzyme, hSCCE, SCCE, KLK7, Kallikrein-7

Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

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Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His)
规格 价格/CNY 货期 数量
10 μg ¥ 1,170 5日内发货
50 μg ¥ 3,470 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His) (TMPJ-00544)
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产品描述 Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.
种属 Human
表达系统 Human Cells
标签 C-6His
蛋白编号 AAH32005
别名 PRSS6, Serine Protease 6, hK7, Stratum Corneum Chymotryptic Enzyme, hSCCE, SCCE, KLK7, Kallikrein-7
氨基酸序列 Glu23-His252
蛋白构建 Recombinant Human Kallikrein 7 is produced by our Mammalian expression system and the target gene encoding Glu23-His252 is expressed with a 6His tag at the C-terminus.
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 30 KDa, reducing conditions
内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.
存储

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

运输方式

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

研究背景 Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

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Keywords

Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His) PRSS 6 PRSS6 Serine Protease 6 hK7 KLK-7 KLK 7 Stratum Corneum Chymotryptic Enzyme PRSS-6 hSCCE SCCE KLK7 Kallikrein-7 recombinant recombinant-proteins proteins protein

 

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