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IL-23R Protein, Cynomolgus, Recombinant (His)

产品编号 TMPK-00652

别名: IL-23 R, IL-23 receptor, IBD17

IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5.

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IL-23R Protein, Cynomolgus, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,100		5日内发货
500 μg	￥ 12,400		5日内发货
1 mg	￥ 20,700		5日内发货

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生物活性

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参考文献

生物活性	1. Immobilized Cynomolgus IL-23R, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.25μg/ml determined by ELISA (QC Test). 2. Cynomolgus IL-23R, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-23 alpha&Mouse IL-12 beta, His Tag with an affinity constant of 3.90 nM as determined in SPR assay.
产品描述	IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5.

种属	Cynomolgus
表达系统	HEK293
标签	C-His
蛋白编号	G7NWY5
别名	IL-23 R, IL-23 receptor, IBD17
蛋白构建	Recombinant Cynomolgus IL-23R Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly24-Asp353.[Accession \|G7NWY5]
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	The protein has a predicted MW of 39.03 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.

参考文献

1. Campa M, et al. A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis[J]. Dermatology and Therapy, 2016, 6(1):1-12.

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Keywords

IL-23R Protein, Cynomolgus, Recombinant (His) IBD-17 IL-23 R IL-23 receptor IBD 17 IBD17 recombinant recombinant-proteins proteins protein

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