IL-17RD Protein, Human, Recombinant (hFc)

Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

规格	价格/CNY		数量
10 μg	￥ 680	5日内发货
50 μg	￥ 2,060	5日内发货
500 μg	￥ 12,400	5日内发货
1 mg	￥ 18,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 680

5日内发货

50 μg

￥ 2,060

5日内发货

500 μg

￥ 12,400

5日内发货

1 mg

￥ 18,700

5日内发货

产品描述

种属	Human
表达系统	Human Cells
标签	C-Fc
蛋白编号	Q8NFM7
别名	IL17Rhom, IL17RD, IL-17RD, IL-17 RD, IL17RLM, SEF, interleukin 17 receptor D, IL-17RDIL-17 receptor D
氨基酸序列	Cys17-Arg299
蛋白构建	Recombinant Human Interleukin-17 Receptor D is produced by our Mammalian expression system and the target gene encoding Cys17-Arg299 is expressed with a human IgG1 Fc tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	75-90 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

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IL-17RD Protein, Human, Recombinant (hFc)

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