IL-17A Protein, Cynomolgus, Recombinant (His)

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

规格	价格/CNY		数量
10 μg	￥ 780	5日内发货
50 μg	￥ 2,360	5日内发货
500 μg	￥ 13,400	5日内发货
1 mg	￥ 20,100	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 780

5日内发货

50 μg

￥ 2,360

5日内发货

500 μg

￥ 13,400

5日内发货

1 mg

￥ 20,100

5日内发货

生物活性

1. Loaded Biotinylated Human IL-17RA-Fc on Pro A Biosensor, can bind Cynomolgus IL-17A-His with an affinity constant of 0.33 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Cynomolgus IL-17A-His at 2μg/ml (100 μl/well)can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 0.128 ug/ml. (Regularly tested)

产品描述

种属	Cynomolgus
表达系统	Human Cells
标签	C-6His
蛋白编号	G7P4U9
别名	CTLA-8, CTLA8, IL17A, IL-17, IL-17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, Interleukin-17A, IL17
氨基酸序列	Gly24Ala155
蛋白构建	Recombinant Cynomolgus Interleukin-17A is produced by our Mammalian expression system and the target gene encoding Gly24Ala155 is expressed with a 6His tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	15-25 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

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IL-17A Protein, Cynomolgus, Recombinant (His)

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